摘要
目的分析急性脑卒中早期患者肠道菌群失调的影响因素。方法选取本院收治的52例急性脑卒中早期肠道菌群失调患者作为研究组,以同期肠道菌群正常的脑卒中患者75例作为对照组,收集2组患者使用全肠外营养、质子泵抑制剂、抗生素等情况,以及内毒素水平、白细胞计数、基础病史等资料,多因素Logistic回归分析影响急性脑卒中患者早期肠道菌群失调的危险因素。结果研究组患者高血压、糖尿病患病情况,血管活性药物、全肠外营养、质子泵抑制剂使用情况及内毒素水平与对照组比较差异均有统计学意义(均P<0.05或P<0.01);白细胞和血小板计数,神经系统、呼吸系统和心血管系统疾病患病情况及抗生素使用种类,两组间比较差异均无统计学意义(均P>0.05)。多因素Logistic回归分析显示,高血压、糖尿病、高水平内毒素均为急性脑卒中早期患者肠道菌群失调发生的独立危险因素(均P<0.05),而使用血管活性药物、全肠外营养及质子泵抑制剂并非危险因素(均P>0.05)。结论高血压、糖尿病及高水平内毒素为急性脑卒中早期患者肠道菌群失调发生的独立危险因素,应及时采取相应预防和控制措施,以降低急性脑卒中患者早期发生肠道菌群失调的几率,改善患者预后。
Objective To analyze the factors influencing an imbalance in intestinal flora in patients with early acute stroke in order to provide a reference for the clinical prevention and treatment of that condition. Methods Subjects were 52 patients with an imbalance in intestinal flora in the early stage of acute stroke seen at this hospital from March 2019 to March 2021. These patients served as the study group, and 75 stroke patients with normal intestinal flora during the same period served as the control group. The use of total parenteral nutrition and proton pump inhibitors, the types of antibiotics, basic medical history, and other data were collected from the two groups, the endotoxin level, platelet count, and white blood cell count were measured, and multivariate logistic regression was used to analyze the risk factors for an imbalance in intestinal flora in the early stage of acute stroke. Results The study group and the control group differed significantly in terms of hypertension(38.46% vs. 13.33%, P<0.01), diabetes(44.23% vs. 12.00%, P<0.01), vasoactive drugs(40.38% vs. 21.33%, P<0.05), total parenteral nutrition(30.77% vs. 5.33%, P<0.01), proton pump inhibitors(69.23% vs. 36.00%, P<0.01), and endotoxin levels(0.21±0.07 EU/ml vs. 0.14±0.04 EU/ml, P<0.01). However, the white blood cell count, platelet count, nervous system disease, respiratory system disease, cardiovascular system disease, and the types of antibiotics used did not differ significantly(P>0.05 for all). Multivariate logistic regression analysis indicated that hypertension(OR=1.759, 95% CI=1.412-2.191), diabetes(OR=1.645, 95% CI=1.081-2.502), and a higher endotoxin level(OR=1.476, 95% CI=1.416-1.538) were all independent risk factors that affected the imbalance in intestinal flora in the early stage of acute stroke(P<0.05 for all) while vasoactive drugs, total parenteral nutrition, and proton pump inhibitors were not risk factors(P>0.05 for all). Conclusion Hypertension, diabetes and a high level of endotoxin are independent risk factors affec
作者
顾微
姜艳
刘振宁
GU Wei;JIANG Yan;LIU Zhen-ning(Department of Emergency,Shengjing Hospital of China Medical University,Shenyang,Liaoning 110004,China)
出处
《中国病原生物学杂志》
CSCD
北大核心
2021年第8期943-946,共4页
Journal of Pathogen Biology
