摘要
目的分析急性脑卒中消化道出血患者使用泮托拉唑的效果。方法选取2021年1月至12月重庆市巴南区中医院收治的300例急性脑卒中消化道出血患者作为研究对象,采用随机数字表法将其分为试验组和对照组,每组各150例。对照组患者采用综合药物治疗,试验组患者采用泮托拉唑治疗。比较两组患者治疗前后的美国国立卫生研究院卒中量表(NIHSS)评分、消化道出血率和治疗1个月后的死亡率、不良反应总发生率。结果治疗后,两组患者的NIHSS评分均低于治疗前,且试验组患者的NIHSS评分低于对照组,差异有统计学意义(P<0.05)。试验组患者的消化道出血率、治疗1个月后的死亡率低于对照组,差异有统计学意义(P<0.05)。两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论急性脑卒中消化道出血患者使用泮托拉唑治疗能改善患者病情和预后,提高存活率,安全性高,值得推广。
Objective To analyze the effect of Pantoprazole on gastrointestinal bleeding in patients with acute stroke.Methods A total of 300 cases of acute stroke patients with gastrointestinal hemorrhage admitted to Ba′nan District Hospital of Traditional Chinese Medicine in Chongqing from January to December 2021 were selected as the research subjects,and they were divided into experimental group and control group by random number table method,with 150 cases in each group.Patients in control group were treated with comprehensive drug therapy,and patients in experimental group were treated with Pantoprazole.National Institute of Health stroke scale(NIHSS)score before and after treatment,gastrointestinal bleeding rate,mortality after 1 month of treatment and total incidence of adverse reactions were compared between the two groups.Results After treatment,NIHSS scores of the two groups were lower than those before treatment,and NIHSS score of experimental group was lower than that of control group,the differences were statistically significant(P<0.05).The gastrointestinal bleeding rate and mortality after 1 month of treatment in experimental group were lower than those in control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Pantoprazole can improve the condition and prognosis of patients with acute stroke and gastrointestinal bleeding,improve the survival rate,and has high safety.It is worth popularizing.
作者
刘勤
LIU Qin(Department of Pharmacy,Ba′nan District Hospital of Traditional Chinese Medicine,Chongqing401320,China)
出处
《中国当代医药》
CAS
2022年第22期145-147,共3页
China Modern Medicine
