摘要
目的探讨大剂量乳果糖对中度急性胰腺炎腹内高压及肠黏膜屏障功能的影响.方法选取浙江省温州市泰顺县人民医院2015-02/2017-02接诊的90例中度胰腺炎患者作为本次研究的对象,按系统随机化法分为观察组和对照组各45例.在常规对症治疗基础上,对照组给予生长抑素和埃索美拉唑进行治疗,观察组在对照组基础上联合使用大剂量乳果糖进行治疗,对比分析两组患者住院时间、腹痛腹胀缓解时间、肠道恢复时间、治疗前后腹内高压、肠道黏膜屏障功能及治疗效果等情况.结果观察组住院时间、腹痛腹胀缓解时间、肠道恢复时间等临床症状指标均低于对照组,差异有统计学意义(P<0.05);观察组治疗后的腹内高压、内毒素、D-乳酸、二胺氧化酶及尿淀粉酶水平均低于对照组(P<0.05);观察组总有效率(95.11%)高于对照组(80.00%)(P<0.05).结论在生长抑素和埃索美拉唑基础上联合使用大剂量乳果糖对中度胰腺炎患者具有较好疗效,能降低其腹内高压和内毒素、D-乳酸、二胺氧化酶及尿淀粉酶水平,增强肠道黏膜屏障功能,提高临床治疗效果,有利于患者预后,临床价值较高,值得推广应用.
AIM To investigate the effect of high dose lactulose on intraabdominal hypertension and intestinal mucosal barrier function in patients with moderate acute pancreatitis.METHODS Ninety patients with moderate acute pancreafifis admitted to Taishun County People＇s Hospital from February 2015 to February 2017 were included and randomly divided into an observation group and a control group, with 45 cases in each group. On the basis of conventional symptomatic treatment, both groups were treated with somatostatin and esomeprazole, and the observation group was additionally treated with high dose lactulose. Hospitalization time, time to abdominal pain relief, time to intestinal function recovery, intra-abdominal hypertension, intestinal mucosal barrier function, and therapeutic effect were compared between the two groups.RESULTS Hospitalization time, time to abdominal pain relief, and time to intestinal function recovery were significantly shorter in the observation group than in the control group （P 〈 0.05）. Intra-abdominal hypertension） endotoxin, D-lactic acid, diamine oxidase, and urinary amylase levels in the observation group after treatment were lower than those in the control group （P 〈 0.05）. The total effective rate in the observation group （95.11%） was higher than that in the control group （80.00%; P 〈 0.05）.CONCLUSION The combination of high dose lactulose with somatostatin and esomeprazole can reduce intra-abdominal hypertension and endotoxin, D-lactic acid, diamine oxidase, and urinary amylase levels and enhance intestinal mucosal barrier function in patients with moderate acute pancreatitis.
作者
陈旭秀
刘金来
Xu-Xiu Chen;Jin-Lai Liu(Department of Pharmacy, Taishun County People＇s Hospital, Wenzhou 325000, Zhejiang Province, Chin;Department of Pharmacy, Wenzhou People＇s Hospital, Wenzhou 325000, Zhejiang Province, China)
出处
《世界华人消化杂志》
CAS
2018年第15期919-925,共7页
World Chinese Journal of Digestology
关键词
生长抑素
埃索美拉唑
中度胰腺炎
腹内高压:
肠道黏膜屏障功能
疗效
Somatostatin
Esomeprazole
Moderatepancreatitis
Intra-abdominal hypertension
Intestinalmucosal barrier function
Curative effect
