摘要
目的分析CD64、P2X7受体联合cMPO检测在小儿细菌性肺炎诊断、病情评估及预后的应用价值。方法选取2018年11月至2019年11月本科室收治的92例细菌性肺炎患儿作为研究组,根据小儿危重症病例评分法(PCIS)分为两个亚组:重症肺炎患儿(PCIS评分<80分)设为A组(n=40),将轻症肺炎患儿(PCIS评分≥80分)设为B组(n=52);同时纳入同期本院接受健康体检结果正常者98例作为对照组。比较不同人群CD64、P2X7、cMPO水平,采用多元Logistic回归分析影响细菌性肺炎患儿预后生存的独立危险因素,应用ROC曲线分析CD64、P2X7、cMPO对细菌性肺炎患儿预后生存的预测价值。结果研究组患儿CD64、P2X7、cMPO水平显著高于对照组,差异具有统计学意义(P<0.05);A组患儿CD64、P2X7、cMPO水平显著高于B组,差异具有统计学意义(P<0.05);对92例细菌性肺炎患儿进行预后随访显示,8例患儿死亡,死亡率为8.69%。通过Logistic回归模型分析显示:CRP≥100 mg/L、WBC≥12×109/L、PCT≥0.5μg/mL、CD64、P2X7、cMPO异常升高与细菌性肺炎患儿预后生存呈正相关(P<0.05);ROC曲线分析显示:CD64、P2X7、cMPO及三者联合下面积为0.806、0.781、0.800、0.969,以联合检测下面积值最大。结论 CD64、P2X7联合cMPO检测细菌性肺炎患儿诊断价值高,其水平变化与患儿预后密切相关,临床工作者应加强对其指标检测具有重要意义。
Objective To analyze the values of CD64 and P2X7 receptor combined with cMPO in the diagnosis,disease evaluation and prognosis of bacterial pneumonia of children.Methods 92 children with bacterial pneumonia admitted to this hospital from November 2018 to November 2019 were selected as the study group.According to the pediatric critical illness score(PCIS),they were divided into two subgroups:children with severe pneumonia(PCIS score<80) were set as group A(n=40),and children with mild pneumonia(PCIS score≥ 80 points) were set as group B(n=52).98 patients with normal results of physical examination in our hospital during the same period were included as the control group.The levels of CD64,P2X7,and cMPO in different people were compared.Multivariate Logistic regression analysis was used to analyze the independent risk factors affecting the prognosis survival of children with bacterial pneumonia,and the ROC curve was used to analyze the predictive values of CD64,P2X7,cMPO for the prognostic survival of children with bacterial pneumonia.Results The levels of CD64,P2X7 and cMPO in the study group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).The levels of CD64,P2X7 and cMPO in group A were significantly higher than those in group B,and the difference was statistically significant(P<0.05).Prognostic follow-up of 92 children with bacterial pneumonia showed that 8 children died and the mortality rate was 8.69%.Logistic regression model analysis showed that:CRP≥ 100 mg/L,WBC≥ 12 x109/L,PCT≥ 0.5 μg/mL,CD64,P2X7,cMPO abnormal increase was positively correlated with the prognostic survival of children with bacterial pneumonia(P<0.05).The ROC curve analysis showed that CD64,P2X7,cMPO and the combined area of the three were 0.806,0.781,0.800,and 0.969,respectively.The combination of the three is the largest.Conclusion The detection of CD64,P2X7 and cMPO in children with bacterial pneumonia is of high diagnostic value,and changes in their levels are
作者
徐超
李超
蒋勇
XU Chao;LI Chao;JIANG Yong(Department of Pediatrics,Shiyan Taihe Hospital,Shiyan,Hubei,China,442000)
出处
《分子诊断与治疗杂志》
2021年第9期1461-1464,共4页
Journal of Molecular Diagnostics and Therapy
基金
湖北省自然科学基金(2018CFB513)。
