摘要
目的分析婴幼儿阻塞性黄疸的发病概况、退黄率及肝硬化率。方法回顾性分析2020年2—8月在郑州大学附属儿童医院儿童肿瘤外科接受治疗的52例婴幼儿阻塞性黄疸患儿的临床资料。其中36例出生2周内即发生黄疸并进行性加重的为先天阻塞性黄疸(先天组);16例出生后正常,2周后逐渐出现阻塞性黄疸症状的为后天阻塞性黄疸(后天组)。比较两组患儿胆道闭锁(BA)、胆汁淤积症及胆管发育不良等情况,并对两组患儿退黄率及肝硬化率进行分析。结果先天组36例阻塞性黄疸患儿中BA 32例(88.9%)、胆汁淤积症4例(11.1%);后天组16例阻塞性黄疸患儿中BA 10例(62.5%)、胆汁淤积症4例(25.0%)、胆管发育不良2例(12.5%)。两组患儿BA、胆汁淤积症及胆管发育不良情况比较,差异有统计学意义(P<0.05)。先天组及后天组BA患儿退黄率分别为75.0%(24/32)、40.0%(4/10),差异有统计学意义(P<0.05);先天组及后天组BA患儿肝硬化率分别为37.5%(12/32)、60.0%(6/10),差异无统计学意义(P>0.05)。结论先天组与后天组BA、胆汁淤积症及胆管发育不良的发生情况存在差异,且先天组BA患儿退黄率高于后天组。
Objective To analyze the incidence,the refund rate of yellow and the rate of liver cirrhosis of obstructive jaundice in infants.Methods The clinical data of 52 infants with obstructive jaundice who were treated in the Department of Pediatric Oncology Surgery of Children’s Hospital Affiliated of Zhengzhou University from February 2020 to August 2020 were analyzed retrospectively.Among them,36 patients who developed jaundice within 2 weeks of birth and got worse were the congenital obstructive jaundice(congenital group).Sixteen cases with normal postpartum and progressive obstructive jaundice after 2 weeks were acquired obstructive jaundice(acquired group).The biliary atresia(BA),cholestasis,bile duct dysplasia,the refund rate of yellow and the rate of liver cirrhosis were compared between the two groups.Results Among the 36 children with obstructive jaundice in congenital group,32 cases(88.9%)were BA and 4 cases(11.1%)were intrahepatic cholestasis.Among the 16 children with obstructive jaundice in acquired group,10 cases(62.5%)were BA,and 4 cases(25.0%)were intrahepatic cholestasis,and 2 cases(12.5%)were bile duct dysplasia.There were statistical differences in the incidences of BA,intrahepatic cholestasis and bile duct dysplasia between congenital group and acquired group(P<0.05).The refund rates of yellow of BA in congenital group and acquired group were 75.0%(24/32)and 40.0%(4/10),respectively,and there was statistical difference between the two groups(P<0.05).However,the rates of liver cirrhosis in children with BA in congenital group and acquired group were 37.5%(12/32)and 60.0%(6/10),respectively,and there was no statistical difference between the two groups(P>0.05).Conclusion There are differences in the occurrences of BA,cholestasis and bile duct dysplasia between congenital group and acquired group.The refund rate of yellow of children with BA in congenital group is higher than that in acquired group.
作者
张飞
冯全德
侯栋亮
王焕民
张万存
张现伟
ZHANG Fei;FENG Quande;HOU Dongliang;WANG Huanmin;ZHANG Wancun;ZHANG Xianwei(Department of Pediatric Oncology Surgery,Children’s Hospital Affiliated of Zhengzhou University,Zhengzhou 450018,China)
出处
《河南医学研究》
CAS
2021年第28期5212-5215,共4页
Henan Medical Research
基金
中国博士后面上项目(2020M672301)
河南省科技厅科技攻关项目(202102310068)
河南省医学科技攻关项目(LHGJ20190937,HGJ20190887,2018020622)。
关键词
婴幼儿
阻塞性黄疸
胆道闭锁
胆汁淤积症
退黄率
肝硬化率
infant
obstructive jaundice
biliary atresia
cholestasis
refund rate of yellow
rate of liver cirrhosis
