摘要
2型糖尿病(Type 2 Diabetes Mellitus,T2DM)是一种多因素的代谢性疾病,其患病率增长迅速,但发病机制至今未明。研究表明,丙二醛(Malondialdehyde,MDA)、谷胱甘肽过氧化物酶(Glutathione peroxidase,GSH-Px)及氧化型烟酰胺腺嘌呤二核苷酸(Nicotinamide adenine dinucleotide,NAD+)和还原型烟酰胺腺嘌呤二核苷酸(Reduced form of nicotinamide-adenine dinucleotide,NADH)氧化还原的失衡可能通过多种途径与氧化应激相互作用,从而可能与T2DM的发生相关。本文综合近年来针对上述关系机制的相关研究,讨论MDA、GSH-Px、NAD+/NADH氧化还原失衡与T2DM的关系,为T2DM发病机制的探索及防治寻找新方向。
Type 2 Diabetes Mellitus(T2DM)is a multifactorial metabolic disorder with rapidly increasing prevalence and no fully understood pathogenesis.Studies have shown that the imbalance of Malondialdehyde(MDA),glutathione peroxi⁃dase(GSH-Px),and NADH/NAD redox imbalance may interact with oxidative stress through a variety of pathways,which may be correlated with the occurrence of T2DM.In this paper,the relationship between MDA,GSH-Px,NAD+/NADH redox imbalance and T2DM was discussed based on the recent studies on the abovementioned relationship mecha⁃nism,so as to find a new direction for the exploration of the pathogenesis of T2DM and its prevention and treatment.
作者
范茗华
罗晓婷
FAN Ming-hua;LUO Xiao-ting(Undergraduate majoring in clinical medicine of Gannan Medical University,Grade 2017,Ganzhou,Jiangxi 341000;Department of Biochemistry and Molecular Biology of Gannan Medical University,Ganzhou,Jiangxi 341000)
出处
《赣南医学院学报》
2021年第9期900-904,共5页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
基金
国家自然科学基金项目(81660566)
心脑血管疾病防治教育部重点实验室开放课题(XN201907)
国家级大学生创新创业项目(201910413007,20200413003)
赣南医学院本科生科技创新项目(BKSZR201909)。
