摘要
目的:分析采用鼻渊通窍颗粒对老年阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的血清及炎症因子的影响。方法:在本院2016年1月-2019年1月治疗的阻塞性睡眠呼吸暂停低通气综合征老年患者中随机抽取120例作为研究对象,并借助计算机随机分组软件将其分为观察组和对照组,各60例,其中对照组患者在予以常规治疗措施(指导健康饮食、调整睡眠体位等)基础上辅以持续气道正压通气(CPAP)治疗,而观察组患者则在对照组治疗措施基础上予以鼻渊通窍颗粒治疗,比较两组炎性因子指标、睡眠指标等以评价疗效。结果:治疗后观察组和对照组患者的hs-CRP、IL-6、TNF-α、IL-1水平较治疗前均降低,且观察组患者降低更显著(P<0.05);和治疗前相比,治疗后观察组和对照组患者的睡眠指标如AHI、MAI明显降低,而LSaO2则明显升高,观察组优于对照组(P<0.05);和治疗前相比,治疗后观察组和对照组患者的ESS和FSS量表评分均降低,且观察组降低更显著(P<0.05)。结论:将鼻渊通窍颗粒用于阻塞性睡眠呼吸暂停低通气综合征老年患者治疗中,不仅可以提高治疗效果,改善临床症状和通气质量,还能够降低机体血清炎性因子水平,值得推广和应用。
Objective:To analyze the effect of Biyuan Tongqiao Granule on serum and inflammatory factors in elderly patients with obstructive sleep apnea hypopnea syndrome (OSAHS).Method:A total of 120 elderly patients with obstructive sleep apnea hypopnea syndrome treated in our hospital from January 2016 to January 2019 were randomly selected as the research subjects and divided into observation group and control group with the help of computer random grouping software,60 cases in each group.The control group patients were given routine treatment measures (guiding healthy diet,guiding healthy diet,etc).The patients in the observation group were treated with Biyuan Tongqiao Granule on the basis of the control group.The inflammatory factors and sleep indicators between the two groups were compared to evaluate the treatment effect.Result:The levels of hs-CRP,IL-6,TNF-α and IL-1 in the observation group and the control group were all lower than those before treatment,and the observation group’s indexes were lower than those in the control group (P<0.05).The sleep indexes such as AHI,MAI after treatment in the observation group and the control group were lower and the LSaO2 was higher than those before treatment,and the observation group were better than the control group (P<0.05).The scores of ESS scale and FSS scale were decreased after treatment than those before treatment,and the decreases in the observation group were lower (P<0.05).Conclusion:The application of Biyuan Tongqiao Granule in the treatment of elderly patients with obstructive sleep apnea hypopnea syndrome can not only improve the therapeutic effect,clinical symptoms and ventilation quality,but also reduce the level of inflammatory factors in body serum.It is worth popularizing and applying.
作者
尹春雷
徐贝贝
刘乃斌
徐建华
YIN Chunlei;XU Beibei;LIU Naibin;XU Jianhua(Qingdao Hospital Affiliated to Shandong First Medical University,Qingdao 266109,China;不详)
出处
《中外医学研究》
2021年第25期51-54,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
阻塞性睡眠呼吸暂停低通气综合征
鼻渊通窍颗粒
持续气道正压通气
炎性因子
Obstructive sleep apnea hypopnea syndrome
Biyuan Tongqiao Granule
Continuous positive airway pressure ventilation
Inflammatory factors
