摘要
阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)是一种累及多器官、多系统的睡眠呼吸疾病,可导致认知损害。目前对OSA相关认知功能的病理生理机制尚不明确,持续气道正压通气(continuous positive airway pressure,CPAP)对于OSA患者认知功能损害是否存在治疗作用,效果如何等重要问题仍未知。OSA患者反复出现间歇性低氧,睡眠结构紊乱,导致大脑结构和功能异常,最终导致OSA患者发生广泛的认知功能受损。合适的CPAP治疗可纠正OSA患者异常的病理生理过程,在一定程度上恢复脑结构及功能连接,改善认知功能。国内OSA患者对于CPAP治疗的接受度和依从性均较差,而CPAP的治疗效果取决于治疗的时机和依从性,因此许多患者没有得到有效治疗。系统阐述CPAP对OSA患者认知功能的影响,可帮助临床医生及患者提高对CPAP治疗的认识,树立正确的观念以达到早期、规范治疗的目的。
Obstructive sleep apnea(OSA)is a kind of sleep-related breathing disorder,involving multiple organs and systems,which can lead to cognitive impairment.At present,the pathophysiological mechanism of cognitive impairment related to OSA is not clear.It is still unknown whether continuous positive airway pressure(CPAP)has therapeutic effect on cognitive impairment in patients with OSA.These patients repeatedly experience intermittent hypoxia and have sleep fragmentation,which results in abnormal brain structure and function,characterizing by extensive cognitive impairment.Appropriate CPAP can correct the abnormal pathophysiological process of OSA patients,restore brain structure and function to a certain extent,and improve cognitive function.Domestic OSA patients have poor acceptance and compliance to CPAP,while the therapeutic effect of CPAP depends on the timing of treatment and compliance,so many patients do not get effective treatment.Systematically expounding the influence of CPAP on the cognitive function of patients with OSA can help clinicians and patients improve their understanding of CPAP treatment and establish a correct concept of early and standardized treatment.
作者
刘婷
欧阳若芸
LIU Ting;OUYANG Ruoyun(Department of Respiratory and Critical Care Medicine,Second Xiangya Hospital,Central South University,Changsha 410011,China)
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2021年第8期865-871,共7页
Journal of Central South University ：Medical Science
基金
国家自然科学基金(81970086)
湖南省自然科学基金(2020JJ4802)。
关键词
阻塞性睡眠呼吸暂停
持续气道正压通气
认知功能
治疗
obstructive sleep apnea
continuous positive airway pressure
cognitive function
treatment
