摘要
目的探讨阻塞性睡眠呼吸暂停综合征患儿血清中IL-6和TNF-α的水平及临床意义。方法纳入2005年8月至2006年2月在本院耳鼻咽喉科住院,并接受手术治疗的100例阻塞性睡眠呼吸暂停综合征(OSAS)患儿和40例自愿接受检测的正常儿童,测定其血清IL-6和TNF-α的水平。结果OSAS患儿血清IL-6和TNF-α的水平要明显高于正常对照组儿童,其差异有统计学意义(P<0.05)。但OSAS患儿血清IL-6、TNF-α水平和睡眠紊乱(AHI)指数之间并无相关性。结论儿童OSAS代表着一个慢性炎症过程,血清IL-6和TNF-α水平的升高与其存在一定的相关性,并可能是这些患儿以后发生心血管疾病的一个危险因素。
Objective To investigate the levels of IL-6 and TNF-α in children with obstructive sleep apnea syndrome （OSAS） and to determine their clinical significance. Methods One hundred children withOSAS in our department from August 2005 to February 2006, and 40 healthy children were enrolled in the study. The serum levels of IL-6 and TNF-a were measured. Results TNF-α were significantly higher Serum levels of IL-6 and in patients with OSAS thanthose in the control group （P〈0.05）. Both IL-6 and TNF-awere not correlated withAHI. Conclusion It is concluded that OSAS is a chronicinflammatory process. A close correlation was observed between high levels of IL-6 and TNF-a and OSAS. High levels of IL-6 and TNF-a account for the risk factors in the development of cardiovascular diseases in children with OSAS.
出处
《中国循证医学杂志》
CSCD
2007年第7期547-549,共3页
Chinese Journal of Evidence-based Medicine
