摘要
目的探讨鼻扩容手术治疗伴有鼻塞症状的阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的效果及肺功能变化。方法选取雅安市人民医院2020年4月至2022年4月拟采取手术治疗的98例伴有鼻塞症状的OSAHS患者进行前瞻性随机临床试验,采用随机数字表法将其分为A组和B组,各49例,A组患者采用鼻扩容手术治疗,B组患者采用传统悬雍垂腾咽成形术治疗;对比两组患者手术后的鼻腔阻力、鼾声指数、鼻呼吸总量、匹兹堡睡眠质量指数(PSQI)、Epworth嗜睡量表评分(ESS)、脑氧饱和度、血氧饱和度指标、肺功能指标、临床治疗效果差异。结果手术后3个月,A组患者的鼻腔阻力、鼾声指数分别为(0.26±0.08)Pa·cm^(-3)·s^(-1)、(97.40±17.00)次/min,低于B组[(0.31±0.10)Pa·cm^(-3)·s^(-1)、(111.80±20.50)次/min],鼻呼吸总量为(8.64±1.62)L,高于B组[(7.52±1.80)L],差异均有统计学意义(P<0.05)。手术后3个月,A组患者的Epworth评分分别为(4.62±1.10)分,低于B组[(5.25±1.36)分],差异有统计学意义(P<0.05)。手术后3个月,A组患者的rSO_(2)、MSaO_(2)测定值分别为(66.04±1.78)%、(86.91±4.40)%,均高于B组[(65.23±1.95)%、(84.42±3.98)%],差异均有统计学意义(P<0.05)。手术后3个月,A组患者的FVC%pred、FEV1%pred测定值分别为(88.78±4.60)%、(90.21±3.85)%,均高于B组[(86.20±4.43)%、(88.42±4.32)%],差异均有统计学意义(P<0.05)。手术后3个月进行临床疗效评价,A组患者的痊愈率为42.86%,显效率38.78%,有效率18.37%,B组痊愈率26.53%,显效率30.61%,有效率38.78%,无效率4.08%,A组疗效优于B组,差异有统计学意义(P<0.05)。结论鼻扩容手术治疗伴有鼻塞症状的OSAHS患者的临床效果肯定,能显著改善脑氧饱和度、肺功能及呼吸功能。
Objective To investigate the effect of nasal dilatation surgery in the treatment of obstructive sleep apnea hypopnea syndrome(OSAHS)with nasal congestion and the changes of lung function.Methods A prospective randomized clinical trial was conducted on 98 OSAHS patients with nasal congestion who were planned to undergo surgery in Ya'an People's Hospital from April 2020 to April 2022,and they were divided into group A and group B with 49 patients in each group according to the random number table.Patients in group A were treated with nasal dilatation surgery,and patients in group B were treated with traditional uvuloplasty.The nasal resistance,snoring index,total nasal respiration,Pittsburgh sleep quality index(PSQI),Epworth sleepiness scale score(ESS),cerebral oxygen saturation,blood oxygen saturation index,pulmonary function index and clinical treatment effect of the two groups were compared at 3 months after operation.Results The nasal resistance and snore index of group A at 3 months after operation were(0.26±0.08)Pa·cm^(-3)·s^(-1),(97.40±17.00)times/min,respectively,which were lower than those of group B[(0.31±0.10)Pa·cm^(-3)·s^(-1),(111.80±20.50)times/min],and the total nasal respiration was(8.64±1.62)L,which was higher than that of group B[(7.52±1.80)L],the differences were statistically significant(P<0.05).The Epworth score of group A at 3 months after operation was(4.62±1.10)points,which was lower than that of group B[(5.25±1.36)points],the difference was statistically significant(P<0.05).The rSO_(2) and MSaO_(2) values of group A at 3 months after operation were(66.04±1.78)%,(86.91±4.40)%,respectively,which were higher than those of group B[(65.23±1.95)%,(84.42±3.98)%],and the differences were statistically significant(P<0.05).Before operation,there was no statistically significant difference in FVC%pred and FEV1%pred between group A and group B(P>0.05).The FVC%pred and FEV1%pred of group A at 3 months after operation were(88.78±4.60)%,(90.21±3.85)%,respectively,which were higher than th
作者
朱玉博
朱荣飞
程蕾蕾
王雪治
徐艳红
ZHU Yu-bo;ZHU Rong-fei;CHENG Lei-lei(Department of Otolaryngology Head and Neck Surgery,Ya'an People's Hospital,Ya'an Sichuan 625000,China)
出处
《临床和实验医学杂志》
2023年第8期859-863,共5页
Journal of Clinical and Experimental Medicine
基金
四川省雅安市科技计划项目(编号:21KJJH0004)。
