摘要
目的探讨补元复骨汤加减治疗骨折不愈合的临床疗效。方法选取2017年3月至2019年3月本院骨科收治的骨折术后不愈合患者50例,随机分为固定组和中药组,每组25例。固定组行交锁髓内钉固定植骨术,中药组行交锁髓内钉固定植骨术联合中药治疗,比较两组疗效指标、愈合指标、骨代谢指标和不良反应发生率。结果中药组住院时间短于固定组,踝关节评分、膝关节评分均高于固定组,骨密度T值、视觉模拟疼痛评分、中医证候积分均低于固定组,差异有统计学意义(P<0.05)。中药组骨痂生长(骨折断端边缘形态、边缘形态、密度、形成量)评分高于固定组,骨折愈合(骨性愈合、临床愈合)时间短于固定组,差异有统计学意义(P<0.05)。中药组括碱性磷酸酶、骨钙素、骨形态发生蛋白、胰岛素样生长因子水平均低于固定组,差异有统计学意义(P<0.05)。中药组不良反应发生率低于固定组,差异有统计学意义(P<0.05)。结论补元复骨汤加减能有效促进骨折愈合并提高临床治疗的安全性,值得临床推广运用。
Objective To explore the clinical effect of Buyuan Fugu Decoction in the treatment of fracture nonunion.Methods 50 patients with postoperative nonunion of fracture treated in the Department of Orthopedics of our hospital from March 2017 to March 2019 were randomly divided into fixation group and traditional Chinese medicine group,with 25 cases in each group.The fixation group was treated with interlocking intramedullary nail fixation and bone grafting,and the traditional Chinese medicine group was treated with interlocking intramedullary nail fixation and bone grafting combined with traditional Chinese medicine.The curative effect indexes,healing indexes,bone metabolism indexes and the incidence of adverse reactions were compared between the two groups.Results The hospitalization time in the traditional Chinese medicine group was shorter than that in the fixation group,the ankle score and knee score were higher than those in the fixation group,and the bone mineral density T value,visual analog pain score and TCM syndrome score were lower than those in the fixation group(P<0.05).The score of callus growth(fracture edge shape,edge shape,density and formation)in the traditional Chinese medicine group was higher than that in the fixation group,and the time of fracture healing(bone healing and clinical healing)was shorter than that in the fixation group(P<0.05).The levels of alkaline phosphatase,osteocalcin,bone morphogenetic protein and insulin-like growth factor in the traditional Chinese medicine group were lower than those in the fixation group(P<0.05).The incidence of adverse reactions in the traditional Chinese medicine group was lower than that in the fixation group,and the difference was statistically significant(P<0.05).Conclusion Buyuan Fugu Decoction can effectively promote fracture healing and improve the safety of clinical treatment,which is worthy of clinical application.
作者
王卫国
赵明华
WANG Weiguo;ZHAO Minghua(Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan,Shandong,250014,China)
出处
《当代医学》
2021年第29期77-79,共3页
Contemporary Medicine
基金
山东省中医药科技发展计划项目(2017-066)。
关键词
骨折不愈合
补元复骨汤
实验
临床研究
Fracture nonunion
Buyuan Fugu Decoction
Experiment
Clinical research
