摘要
目的探讨丙种球蛋白联合利奈唑胺治疗新生儿败血症的临床效果。方法选择2017年5月至2020年5月我院收治的102例败血症新生儿,根据新生儿家长意愿分为两组各51例。两组患儿均进行常规治疗,对照组采用利奈唑胺治疗,观察组在对照组基础上采用丙种球蛋白治疗。两组均治疗3 d。比较两组的临床疗效及血清相关指标。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗3 d后,两组的血清免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平升高,C反应蛋白(CRP)水平下降,且观察组的IgG、IgM水平高于对照组,CRP水平低于对照组(P<0.05)。结论丙种球蛋白联合利奈唑胺治疗新生儿败血症,可降低机体炎性反应,改善机体免疫功能,具有较好的治疗效果。
Objective To explore the clinical effect ofγglobulin combined with linezolid in the treatment of neonatal sepsis.Methods 102 neonates with sepsis admitted to our hospital from May 2017 to May 2020 were selected and divided into two groups according to the wishes of parents,with 51 cases in each group.Both groups received conventional treatment.The control group was treated with linezolid,and the observation group was treated withγglobulin on the basis of the control group.Both groups were treated for 3 days.The clinical efficacy and serum related indicators were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After 3 days of treatment,the serum immunoglobulin G(Ig G)and immunoglobulin M(Ig M)levels of the two groups increased,and the C-reactive protein(CRP)levels decreased(P<0.05);The Ig G and Ig M levels of the observation group were higher than those of the control group,and the CRP level was lower than that of the control group(P<0.05).Conclusionsγglobulin combined with linezolid in the treatment of neonatal sepsis can reduce body’s inflammatory response,and improve body’s immune function,with better treatment effect.
作者
焦洋
赵楠
蒋伟峰
JIAO Yang;ZHAO Nan;JIANG Weifeng(NICU,Shangqiu First People's Hospital,Shangqiu 476000,China)
出处
《临床医学工程》
2021年第9期1197-1198,共2页
Clinical Medicine & Engineering
