摘要
目的:探讨光谱CT、MRI以及血清甲胎蛋白(AFP)及肿瘤标志物糖类抗原19-9(CA19-9)的表达在原发性肝癌诊断中的临床价值。方法:选取医院收治的80例原发性肝癌(PHC)患者作为观察组,选择同期就诊的80例肝硬化患者作为对照组。采集两组患者空腹静脉血,使用Elisa试剂盒检测血清中AFP和CA19-9的表达水平,使用双层探测器能谱CT对患者行腹部平扫和肝脏双期扫描,采用超导型磁共振扫描仪和体部相控阵线圈对患者进行检查。绘制受试者工作特征(ROC)曲线,分析各种检测方法对原发性肝癌的诊断效能。结果:两组血清AFP的表达均有所升高,观察组血清AFP及CA19-9表达水平高于对照组,差异有统计学意义(t=21.881,t=28.559;P<0.05)。采用血清AFP和CA19-9为单一标志物对PHC的检出率分别为68.75%和57.50%,而血清AFP联合CA19-9对PHC的检出率为87.50%。光谱CT和MRI单独检测对PHC的检出率分别为88.75%和90.00%,而光谱CT和MRI联合血清AFP和CA19-9检测对PHC的检出率分别为93.75%和96.25%。ROC曲线分析结果符合上述统计结果。结论:光谱CT或MRI联合血清AFP和CA19-9检测对PHC的检出率均高于单一检测方法,且MRI联合血清AFP和CA19-9检测对PHC的检出率最高。MRI联合血清AFP和CA19-9检测对于PHC的早期诊断以及对原发性肝癌的早期筛查具有一定的应用价值。
Objective:To investigate the clinical values of spectral computed tomography(CT),magnetic resonance imaging(MRI),and the expression of serum alpha-fetoprotein(AFP)and carbohydrate antigen19-9(CA19-9)in the diagnosis of primary hepatic carcinoma(PHC).Methods:80 patients with PHC who admitted to hospital were selected and they were divided into observation group,and 80 patients with liver cirrhosis who admitted to hospital at the same time were divided into control group.After the fasting bloods of two groups were collected,the expression levels of AFP and CA19-9 in the serum were detected by using the Elisa kit.The double-layered detector spectral CT was used to perform abdominal plain scan and dual-phase scan of liver.The superconducting type of magnetic resonance scanner and body phased-array coil were adopted to examine these patients.The receiver operating characteristics(ROC)curve was drawn to analyze the diagnostic efficiency of various detection methods on PHC.Results:The expression levels of serum AFP increased in both observation group and control group,and the expression levels of serum AFP and CA19-9 of observation group were significantly higher than those of control group(t=21.881,t=28.559,P<0.05).When the serum AFP and CA19-9 were respectively used as single marker,the relevance ratios of them on PHC were 68.75%and 57.50%.And the relevance ratio that serum AFP combined with CA19-9 was 87.50%for PHC.The relevance ratios of single spectral CT and single MRI were 88.75%and 90.00%on PHC,respectively.And when spectral CT and MRI respectively combined with“serum AFP and CA19-9”,the relevance ratios of them were 93.75%and 96.25%on PHC.The results of ROC curve analysis conformed to above statistic results.Conclusion:The relevance ratio of spectral CT or MRI respectively combines with“serum AFP and CA19-9”is higher than that of any single one,and the relevance ratio of MRI combines with“serum AFP and CA19-9”is the highest.And the detection that MRI combines with“serum AFP and CA19-9”has a cert
作者
唐亮
郑晓东
郑佳连
TANG Liang;ZHENG Xiao-dong;ZHENG Jia-lian(Medical Imaging Center,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China.)
出处
《中国医学装备》
2021年第9期62-66,共5页
China Medical Equipment
