摘要
目的:研究壳聚糖(CTS)对S型变形链球菌(S.Mutans)的抑制作用。方法:对比不同浓度CTS与氟化钠(NaF)及生理盐作用于S.Mutans后的OD值,计算ΔpH。结果:在不同浓度条件下,两种药物作用于S.Mutans测得的OD值不同。随着药物浓度增加,OD值表现为下降趋势。OD值比较,NaF组与对照组相比,差异有统计学意义(P<0.05);CTS组与对照组相比,差异有统计学意义(P<0.05);NaF组与CTS组比较,差异无统计学意义(P>0.05)。实验组ΔpH通常小于对照组,表明对照组培养管内S.Mutans的数量较大而且产酸代谢活跃。在含有抑菌制剂的实验组中,培养管内S.Mutans的产酸能力受到显著抑制。结论:CTS与NaF均能抑制S.Mutans生长,本实验浓度条件下浓度越高,抑菌效果越强。在本实验条件下,CTS的抗菌作用与NaF的抗菌作用比较,差异无统计学意义。
Objective:To study the inhibitory effect of chitosan(CTS)on S.streptococcus mutans(S.Mutans).Methods:The OD values of S.Mutans treated with different concentrations of CTS,Sodium fluoride(NAF)and physiological salts were compared,and calculatedΔpH.Results:At different concentrations,the OD values measured by the two drugs acting on S.Mutans are different.With the increase of drug concentration,OD value showed a downward trend.OD value comparison,there was significant difference between NaF group and control group(P<0.05);there was significant difference between CTS group and control group(P<0.05);there was no significant difference between NaF group and CTS group(P>0.05).TheΔpH of experience group was usually lower than that of the control group,indicating that the number of S.mutans in the culture tube of the control group was larger and the acid production metabolism was active.In the experimental group containing antibacterial agents,the acid production ability of S.mutans in the culture tube was significantly inhibited.Conclusion:Both CTS and NaF can inhibit the growth of S.Mutans,and the higher the concentration in this experiment,the stronger the antibacterial effect.Under the this experimental conditions,there is no significant difference between the antibacterial effect of CTS and NaF.
作者
王从
刘新庆
WANG Cong;LIU Xin-qing(Zhejiang Provincial Integrated Chinese and Western Medicine Hospital,Hangzhou 310003;Jiangxi Provincial People's Hospital,Nanchang 330006)
出处
《实用中西医结合临床》
2021年第16期157-159,共3页
Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine
基金
江西省卫生健康委员科技计划项目(编号:20175060)。
关键词
S型变形链球菌
壳聚糖
氟化钠
S.streptococcus mutans
Chitosan
Sodium fluoride
