摘要
目的探讨老年心脑血管疾病病人颈动脉斑块与BMI、生长激素(growth hormone,GH)之间的关系。方法选取我院住院的老年心脑血管疾病病人198例,根据颈动脉彩色多普勒超声检查结果是否有颈动脉斑块形成分为斑块组(170例)和非斑块组(28例)。观察并比较2组BMI、GH水平及相关临床生化指标的差异,采用多因素Logistic回归分析颈动脉斑块形成的影响因素,采用Pearson相关系数描述GH、BMI及生化指标间的相关性。结果斑块组与非斑块组在年龄、性别、吸烟史、饮酒史,高血压、糖尿病患病率及BMI、TG、TC、FPG、载脂蛋白A1、GH水平间差异均有统计学意义(P<0.05)。Logistic回归分析显示,年龄、吸烟史、饮酒史、高血压、糖尿病、GH、BMI、TG、TC是颈动脉斑块发生的影响因素(P<0.05)。Pearson相关分析显示,GH与BMI、TC、TG、FPG呈负相关;BMI与TC、TG、FPG呈正相关。趋势卡方检验提示,随着GH水平的降低和BMI的升高,斑块检出率升高(P<0.01)。结论老年心脑血管疾病病人颈动脉斑块的发生受多种因素共同作用,年龄、吸烟史、饮酒史、高血压、糖尿病、BMI、TC、TG是其发生的危险因素,GH是其发生的保护因素。老年人应重视合理膳食、适当锻炼、改变生活习惯,降低颈动脉斑块的发生率。
Objective To explore the relationship of carotid plaque with body mass index(BMI)and growth hormone(GH)in the elderly patients with cardiovascular and cerebrovascular diseases.Methods A total of 198 hospitalized elderly patients with cardiovascular and cerebrovascular diseases were selected and divided into plaque group(170 cases)and non-plaque group(28 cases)according to the results of color Doppler ultrasound examination on the carotid artery.The levels of BMI and GH and the related clinical biochemical indexes were observed and compared between the two groups.Multivariate Logistic regression analysis was used to analyze the influencing factors for carotid artery plaque,and Pearson correlation analysis was used to analyze the correlation between the GH,BMI and the biochemical index.Results There were significant differences in age,gender,smoking history,drinking history,the prevalence rate of hypertension and diabetes,the levels of BMI,triglyceride(TG),total cholesterol(TC),fasting plasma glucose(FPG),apolipoprotein A1 and GH between plaque group and non-plaque group(P<0.05).Logistic regression analysis showed that age,smoking history,drinking history,hypertension,diabetes,GH,BMI,TG,TC were the influencing factors for the occurrence of carotid plaque(P<0.05).Pearson correlation analysis showed that GH was negatively correlated with BMI,plaque detection rate,TC,TG and FPG,while BMI was positively correlated with TC,TG and FPG.The results of trend chi-square test showed that plaque detection rate increased with the decrease of GH level and the increase of BMI(P<0.01).Conclusions The occurrence of carotid plaques in the elderly patients with cardiovascular and cerebrovascular diseases is influenced by various factors.Age,history of smoking and drinking,hypertension,diabetes,BMI,TC,TG are the risk factors,while GH level is the protective factor.It is important to pay attention to the rational diet,proper exercise,changes in lifestyle,so as to reduce the incidence of carotid plaques.
作者
郭万申
樊双义
GUO Wan-shen;FAN Shuang-yi(Department of Neurology, the Fifth Medical Center of Chinese PLA General Hospital,Beijing 100071,China)
出处
《实用老年医学》
CAS
2021年第9期935-938,共4页
Practical Geriatrics
基金
军事医学创新工程项目(16CZX028)。
