摘要
目的探讨益经护巢汤联合来曲唑及地屈孕酮治疗卵巢功能减退性不孕症的临床疗效以及对患者血清性激素、白细胞介素-21(IL-21)水平及妊娠结局的影响。方法115例卵巢功能减退性不孕症患者依据不同治疗方案分为两组,西药组(n=56)予来曲唑+地屈孕酮治疗,联合组(n=59)予益经护巢汤+来曲唑+地屈孕酮治疗,连续治疗6个月经周期后,对比两组疗效、妊娠结局,并测定治疗前后血清性激素指标、IL-21水平。结果联合组总有效率89.83%显著高于西药组75.00%(P<0.05);治疗后,两组雌二醇(E_(2))水平升高,睾酮(T)、促黄体生成素(LH)、促卵泡生成激素(FSH)、IL-21水平降低,且联合组E2水平显著高于西药组,T、LH、FSH及IL-21水平显著低于西药组(P<0.05);联合组妊娠率52.54%高于西药组33.93%(P<0.05);两组流产率及不良反应发生率对比差异无统计学意义(P>0.05)。结论益经护巢汤联合来曲唑及地屈孕酮治疗卵巢功能减退性不孕症疗效显著,能改善患者性激素、IL-21水平,提高短期内自然妊娠率,且不会增加流产率和毒副反应,值得临床推广。
Objective To observe the clinical curative effect of Yi-jing-hu-chao decoction combined with letrozole and dydrogesterone in the treatment of patients with hypo-ovarianism infertility and its influences on serum sex hormones,interleukin-21(IL-21)and pregnancy outcomes.Methods One hundred and fifteen patients with hypo-ovarianism infertility were divided into western medicine group treated with letrozole and dydrogesterone(n=56)and combination group treated with Yi-jing-hu-chao decoction combined with letrozole and dydrogesterone(n=59).After continuous treatments for 6 menstrual cycles,curative effect and pregnancy outcomes were compared between the two groups.The levels of serum sex hormones and IL-21 before and after treatment were detected.Results The total response rate in the combination group was significantly higher than that in the western medicine group(89.83%vs.75.00%,P<0.05).After treatment,the level of estradiol(E_(2))was increased,while levels of testosterone(T),luteinizing hormone(LH),follicle stimulating hormone(FSH)and IL-21 were decreased in both groups.After treatment,E2 level in the combination group was significantly higher than that in the western medicine group,while levels of T,LH,FSH and IL-21 were significantly lower than those in the western medicine group(P<0.05).After treatment,pregnancy rate in the combination group was significantly higher than that in the western medicine group(52.54%vs.33.93%,P<0.05).There was no significant difference in the abortion rate or the incidence of adverse reactions between the two groups(P>0.05).Conclusion The curative effect of Yi-jing-hu-chao decoction combined with letrozole and dydrogesterone is significant in the treatment of patients with hypo-ovarianism infertility.It can improve the levels of serum sex hormones and IL-21,and increase the effect natural pregnancy rate in the short term without increasing abortion rate and side effects.It is worth for clinical promotion.
作者
焦楠
JIAO Nan(Department of Obstetrics and Gynecology,Haozhou Hospital of Traditional Chinese Medicine,Haozhou 236800,China)
出处
《实用医院临床杂志》
2021年第5期116-118,共3页
Practical Journal of Clinical Medicine