摘要
目的 探究备孕营养素对卵巢储备功能减退(DOR)患者体外受精-胚胎移植(IVF-ET)结局的影响。方法 选取120例DOR患者,根据随机数字表法分为对照组与研究组,每组60例。研究组口服备孕营养素干预,对照组口服维生素E干预。比较两组患者基础性激素、超促排卵情况、卵子及胚胎情况和IVF-ET结局。结果 两组干预前后卵泡刺激素(FSH)、促黄体生成素(LH)及雌二醇(E_(2))水平对比,差异无统计学意义(P>0.05)。两组促性腺激素(Gn)剂量、Gn天数对比,差异无统计学意义(P>0.05)。研究组患者干预后正常受精数(2PN数)、优质胚胎数明显多于对照组,差异有统计学意义(P<0.05),两组窦卵泡个数、获卵数、可移植胚胎数对比,差异无统计学意义(P>0.05)。研究组无可移植胚胎周期率低于对照组,差异有统计学意义(P<0.05),两组周期取消率对比,差异无统计学意义(P>0.05)。两组早期流产率对比,差异无统计学意义(P>0.05),研究组临床妊娠率73.33%高于对照组的48.39%,差异有统计学意义(P<0.05)。结论 相比口服维生素E方案,备孕营养素干预效果更优,可显著提升DOR患者正常受精率、优质胚胎数、临床妊娠率,减低无可移植胚胎周期率,改善患者IVF-ET的妊娠结局,减少反复行IVF次数,其为女性不孕症合并DOR患者提供了有效的治疗方案,对改善临床妊娠结局具有积极意义。
Objective To explore the effects of pregnancy preparation nutrients on the outcome of in vitro fertilizationembryo transfer(IVF-ET) in patients with decreasing ovarian reserve(DOR). Methods 120 patients with DOR were selected and divided into control group and study group according to random number table method, with 60 patients in each group. The study group received oral pregnancy preparation nutrient intervention, and the control group received oral vitamin E intervention. Basic sex hormones, superovulation, ovum and embryo, and IVF-ET outcomes were compared between the two groups. Results There was no significant difference in the levels of follicle stimulating hormone(FSH), luteinizing hormone(LH) and estradiol(E2) between the two groups before and after intervention(P>0.05). There was no significant difference in the dose and days of gonadotropin(Gn) between the two groups(P>0.05). After intervention, the number of normal fertilization(2PN) and the number of high-quality embryos in the study group were significantly higher than those in the control group, with statistical significance(P<0.05), but there was no statistical significance in the number of sinus follicles, the number of eggs obtained and the number of transportable embryos between the two groups(P>0.05). The period rate of non-transplantable embryo in the study group was lower than that in the control group, the difference was statistically significant(P<0.05), and the period cancellation rate was not statistically significant between the two groups(P>0.05). There was no significant difference in the rate of early abortion between the two groups(P>0.05). The clinical pregnancy rate of the study group was 73.33% higher than that of the control group(48.39%), with statistical significance(P<0.05). Conclusion Compared with oral vitamin E regimen, the intervention effect of pregnant nutrient is better,which can significantly improve the normal fertilization rate, the number of high-quality embryos and the clinical pregnancy rate of patients with DOR
作者
黄金江
韦静
曲晓力
Huang Jinjiang;WeiJing;Qu Xiaoli(Reproductive Medicine Center,Liuzhou Workers'Hospital,Liuzhou 545000,China)
出处
《实用妇科内分泌电子杂志》
2022年第18期57-60,共4页
Electronic Journal of Practical Gynecological Endocrinology
基金
广西壮族自治区卫生健康委员会自筹经费科研(编号Z20201195)。
关键词
卵巢储备功能减退
备孕营养素
体外受精-胚胎移植结局
卵巢功能
综合疗效
Decreasing ovarian reserve
Pregnant nutrients
In vitro fertilization-embryo transfer outcome
Ovarian function
Comprehensive curative effect
