摘要
目的探究精神分裂症菌群结构特征与临床症状的相关性。方法纳入2018年10月—2019年6月合肥市第四人民医院收治的精神分裂症患者急性发作期(A组)32例,缓解期(B组)30例,健康对照(C组)34人。运用16SrRNA技术分析菌群差异及与临床症状的相关性。结果 (1)另枝菌属A组丰度高于C组(F=2.575,P=0.017),硫杆菌属A组丰度低于C组(F=3.940,P=0.023);巨球型菌属A组、B组丰度高于C组(F=11.720,P<0.001),毛螺菌属、粪球菌属A组、B组丰度低于C组(F=4.279、3.670,均P<0.05);拟杆菌属、嗜血杆菌属、酪酸梭菌属A组丰度高于B组(F=2.977、4.840、2.655,均P<0.05),琥珀酸弧菌属A组丰度低于B组(F=6.190,P=0.003)。(2)小杆菌属与抑郁因子呈负相关(r=-0.269,P=0.034);巨单胞菌属与阳性和阴性症状量表(PANSS)总分呈正相关(r=0.291,P=0.022);拟杆菌属与阳性因子成正相关(r=0.282,P=0.029)。结论精神分裂症急性发作期和缓解期菌群结构改变,且部分菌群相对丰度与临床症状相关。
Objective This study aimed to explore the correlation between the structural characteristics of schizophrenia flora and clinical symptoms. Methods Patients who were diagnosed with schizophrenia in the fourth hospital in Hefei from October 2018 to June 2019 were included in this study: 32 patients in the acute stage(group A), 30 in the remission stage(group B) and 34 in the healthy control group(group C). The 16 SrRNA technique was used to analyse the difference of bacterial flora and its correlation with clinical symptoms. Results(1) The abundance of other mycobacteria in group A was higher than that in group C(F=2.575, P=0.017), whereas the abundance of thiobacillus in group A was lower than that in group C(F=3.940, P=0.023). The abundance of macrococcidia in groups A and B was higher than that of group C(F=11.720, P<0.001), and the abundance of trichoderma and coprococcus in groups A and B was lower than that of group C(F=4.279、3.670, all P<0.05). The abundance of Bacteroidetes, haemophilus and Clostridium tyrosine in group A was higher than that in group B(F=2.977, 4.840;F=2.655, P<0.05), and the abundance of vibrio succinate was lower than that of group B(F=6.190, P=0.003).(2) Microbacilli were negatively correlated with depression factors(r=-0.269, P=0.034). Macrosomonas was positively correlated with the total PANSS score(r=0.291, P=0.022). Bacteroidetes was positively correlated with positive factors(r=0.282, P=0.029). Conclusion The structural changes of the microflora in the acute and remission stages of schizophrenia and the relative abundance of some microflora were correlated with clinical symptoms.
作者
王中娴
张爱国
姚理慧
程夏龙
程鹏
朱翠珍
苏虹
张许来
WANG Zhong-xian;ZHANG Ai-guo;YAO Li-hui;CHENG Xia-long;CHENG Peng;ZHU Cui-zhen;SU Hong;ZHANG Xu-lai(Anhui Metal Health Center,Hefei,Anhui 230022,China;不详)
出处
《中华全科医学》
2021年第9期1530-1534,共5页
Chinese Journal of General Practice
基金
国家自然科学基金项目(81773518)
合肥市科技局“借转补”项目(J2018Y05)。
关键词
精神分裂症
肠道菌群
高通量测序
临床症状
Schizophrenia
Intestinal flora
High-throughput sequencing
Clinical symptoms
