摘要
该研究总结并分析当前辅助改善记忆保健食品及具有类似保健作用中成药的现状,为改善记忆保健食品组方和产品开发提供依据与参考。通过检索国家市场监督管理总局(SAMR)特殊食品安全监督管理司公布的具有辅助改善记忆功能的保健食品信息资料及药智数据网中成药数据库,运用Microsoft Excel软件和中医传承辅助平台统计分析其配方特点,在SAMR共搜集到212种具有辅助改善记忆功能的保健食品,其中83种保健食品配方中含有中药类原料。使用频次≥8的中药原料有12味,累计使用151次。在药智数据网中成药数据库共搜集到258种类似中成药,使用频次≥58的中药原料有12味,累计使用907次。对上述保健食品和中成药各自进行无监督的熵层次聚类,分别得到5个、12个新组方。新组方在中药原料的选择上与中医药改善记忆方法原则基本契合,即补肾益髓、益气养阴、化痰逐瘀。依据中医药理论对保健人群辨证分型,依据方证相应、药证相关有针对性地设计组方,可以为研发中药保健食品提供新思路和新方法,为实际应用提供更加精准的指导,达到充分发挥中医药辨证保健的优势,提高中药保健食品使用效果的目的。
The present study analyzed the current Chinese medicinal health products and Chinese patent medicines effective in boosting memory,aiming at providing references for the formulation and development of memory-boosting health products.The information on memory-boosting health products published by the Department of Special Food Safety Supervision and Management,the State Administration for Market Regulation(SAMR)was collected and the Chinese patent medicines on DRUGDATAEXPY were searched.Microsoft Excel and the TCMISS were used to statistically analyze the characteristics of formulations.A total of 212 memory-boosting health products were obtained from SAMR,including 83 ones containing Chinese medicinal materials.Twelve Chinese herbal medicines showed a usage frequency≥8,with 151 times in use.In DRUGDATAEXPY,258 similar Chinese patent medicines were collected.Twelve Chinese herbal medicines showed a usage frequency≥58,with 907 times in use.Through unsupervised hierarchical entropybased clustering of the above-mentioned Chinese medicinal health products and Chinese patent medicines separately,5 and 12 new formulas were obtained.The selection of Chinese herbal medicines for the new formulas was consistent with the principles of traditional Chinese medicine(TCM)theories,i.e.,tonifying kidney and marrow,benefiting Qi,nourishing Yin,resolving phlegm,and eliminating stasis.According to TCM theories,syndrome differentiation of the users was conducted,and the formulas were designed following the correspondence of syndromes with formulas and Chinese herbal medicines.This study is expected to provide new ideas and methods for the development of Chinese medicinal health products and accurately guide practical applications to exert the advantages of TCM in health care based on syndrome differentiation and improve the effect of Chinese medicinal health products.
作者
张睿
王林元
刘金莲
汤如莹
王禅缔
侯新娟
赵凡
王淳
张建军
ZHANG Rui;WANG Lin-yuan;LIU Jin-lian;TANG Ru-ying;WANG Chan-di;HOU Xin-juan;ZHAO Fan;WANG Chun;ZHANG Jian-jun(Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2021年第13期3222-3227,共6页
China Journal of Chinese Materia Medica
基金
国家重点研发计划项目(2018YFC1706800)。
关键词
改善记忆
保健食品
中成药
中药配伍
数据挖掘
辨证保健
boosting memory
health produts
Chinese patent medicine
compatibility of traditional Chinese medicine
data mining
healthcare based on syndrome differentitation
