摘要
目的系统评价消风散加减治疗荨麻疹的疗效。方法检索中国生物医学文献数据库(CBM)、中国知网(CNKI)、中文科技期刊全文数据库(VIP)、万方数据库、PubMed数据库中公开发表有关消风散加减治疗荨麻疹的临床随机对照试验(RCT)。结果共纳入14篇RCT文献,1635例患者,Meta结果示,治疗组总有效率高于对照组[RR=1.21,95%CI(1.16,1.26),Z=8.67,P<0.00001],改善UAS评分[RR=-0.70,95%CI(-0.83,-0.57),Z=10.56,P<0.00001]、DLQI评分[RR=-1.12,95%CI(-1.88,-0.35),Z=2.87,P=0.004]优于对照组,临床复发率小于对照组[RR=0.23,95%CI(0.09,0.58),Z=3.15,P=0.002]。结论消风散加减治疗荨麻疹效果优于常规西药治疗,且复发率低,但本研究纳入文献较少,且质量偏低,仍需开展多中心、大样本临床随机试验,为临床应用提供可靠的参考依据。
Objective To systematically evaluate the curative effect of Xiaofeng Powder in the treatment of urticaria.Methods Searching the Chinese Biomedical Literature Database(CBM),China Knowledge Network(CNKI),Chinese Science and Technology Journal Full-text Database(VIP),Wanfang Database,and PubMed Database to publish publicly published information about the addition and subtraction of Xiaofeng Powder compared with conventional western medicine in the treatment of urticaria clinical randomized controlled trial(RCT).Results A total of 14 RCT literatures and 1635 patients were included.Meta results showed that the total effective rate of the treatment group was higher than that of the control group[RR=1.21,95%CI(1.16,1.26),Z=8.67,P<0.00001];In improving UAS score[RR=-0.70,95%CI(-0.83,-0.57),Z=10.56,P<0.00001],DLQI score[RR=-1.12,95%CI(-1.88,-0.35),Z=2.87,P=0.004]was better than the control group,and the clinical recurrence rate was lower than that of the control group[RR=0.23,95%CI(0.09,0.58),Z=3.15,P=0.002].Conclusion The effect of modified Xiaofeng Powder in treating urticaria is better than conventional western medicine,and the recurrence rate is low.However,this study included less literature and low quality.It is still necessary to carry out multi-center,large-sample randomized clinical trials to provide reliable reference for clinical applications.
作者
朱明明
沈琴
ZHU Ming-ming;SHEN Qin(The First Clinical College of Hubei University of Chinese Medicine,Wuhan 430065,Hubei,China)
出处
《医学信息》
2021年第18期99-102,共4页
Journal of Medical Information
关键词
消风散
荨麻疹
风团样丘疹
瘙痒
风疙瘩
Xiaofeng Powder
Urticaria
Wind mass-like papules
Pruritus
Wind pimple
