摘要
目的比较帕金森病轻度认知障碍(PD-MCI)和遗忘型轻度认知障碍(aMCI)患者在视觉事件相关反应中δ、θ和α频段的振荡活动特点,探讨PD-MCI患者和aMCI患者认知损伤的电生理学差异,为鉴别PD-MCI和aMCI提供依据。方法本研究为横断面研究。纳入2020年1—10月大连市友谊医院神经内科认知障碍门诊和运动障碍门诊临床确诊的aMCI患者30例(aMCI组)、PD-MCI患者50例[其中使用多巴胺能药物治疗且从中获益者25例作为PD-MCI(A)组,未使用多巴胺能药物治疗者25例作为PD-MCI(B)组]以及本院体检中心招募的年龄、性别及受教育程度相匹配且认知功能正常的健康志愿者28名(正常对照组)。对所有入组者进行神经心理学测试及视觉事件相关振荡反应试验,记录δ、θ和α频段的脑电活动,进行时频分析以了解各频段能量变化及锁相程度并比较各组间的电生理学差异。采用单因素方差分析对人口学资料和神经心理学数据进行统计分析;采用混合设计方差分析对电生理学数据进行统计分析;采用Bonferroni方法进行事后多重比较。结果PD-MCI(A)组和PD-MCI(B)组在全部被研究频段和所有位置的能量值(与aMCI组相比,均P<0.05;与正常对照组相比,均P<0.05)和锁相值(与aMCI组相比,均P<0.05;与正常对照组相比,均P<0.05)均最低,差异有统计学意义。与正常对照组相比,PD-MCI(A)组和PD-MCI(B)组(均P<0.01)与aMCI组(均P<0.05)的θ频段能量值均下降,且PD-MCI(A)组和PD-MCI(B)组较aMCI组的下降均更严重(均P<0.05),差异有统计学意义。仅PD-MCI(A)组和PD-MCI(B)组在全部被研究频段出现相位同步性即锁相程度下降(与aMCI组相比,均P<0.05;与正常对照组相比,均P<0.05),差异有统计学意义;而aMCI组的相位同步性保留。结论PD-MCI患者视觉网络功能比aMCI患者受到更严重的影响。PD-MCI患者的锁相程度下降可能与皮质下调节中枢的功能障碍有关,该中枢在事件相关
Objective To compare Parkinson′s disease with mild cognitive impairment(PD-MCI)and amnestic mild cognitive impairment(aMCI)patients in visual event-related delta,theta,alpha event-related band power and phase-locking measures,explore the electrophysiological differences in cognitive impairment between PD-MCI and aMCI patients,so as to provide evidence for the identification of PD-MCI and aMCI.Methods This study is a cross-sectional study.A total of 30 patients with aMCI(aMCI group)and 50 patients with PD-MCI were recruited from memory outpatient clinic and movement disorders outpatient clinic in Dalian Friendship Hospital between January 2020 and October 2020,and 28 age-,gender-and education-matched cognitively normal healthy control participants(normal control group)from medical center of the hospital served the controls.Among the 50 patients with PD-MCI,25 patients who received dopaminergic medication and benefited from it were assigned to PD-MCI(A)group,and 25 patients who did not receive dopaminergic medication were assigned to PD-MCI(B)group.A comprehensive neuropsychological test was conducted on all participants,using visual event-related delta,theta,alpha oscillatory responses by methods of event-related spectral perturbation and inter-trial coherence and recording the electroencephalogram activity.Time-frequency analysis was performed to obtain power enhancement and phase-locking in delta,theta and alpha frequency bands,and the electrophysiological differences among each group were analyzed.One-way analysis of variance(ANOVA)was used for statistical analysis of demographic information and neuropsychological data.Mixed ANOVA was used for electrophysiological data analyses.Post-hoc analysis was performed by Bonferroni method.Results The lowest power(compared with the aMCI group,P<0.05;compared with the normal control group,P<0.05)and phase-locking values(compared with the aMCI group,P<0.05;compared with the normal control group,P<0.05)were found in the PD-MCI(A)and PD-MCI(B)groups in all frequency bands
作者
杨旭
Yang Xu(Department of Neurology,Dalian Friendship Hospital,Dalian 116001,China)
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2021年第7期655-664,共10页
Chinese Journal of Neurology
关键词
帕金森病
阿尔茨海默病
认知障碍
事件相关
锁相
Parkinson disease
Alzheimer disease
Cognition disorders
Event-related
Phase-locking
