摘要
目的探讨急性冠脉综合征(acute coronary syndrome,ACS)患者血浆可溶性低密度脂蛋白受体相关蛋白1(soluble low-density lipoprotein receptor-related protein-1,sLRP-1)浓度、调解活化正常T细胞表达和分泌趋化因子(regulated upon activation normal T cell expressed and secreted,RANTES)浓度的变化及其与冠状动脉病变严重程度的相关性及其临床意义。方法连续选取2019年1月至2019年7月承德医学院附属医院心内科接受冠脉造影的250例住院患者进行前瞻性研究,包括ACS患者158例、稳定型心绞痛(stable angina pectoris,SAP)42例、对照组50例。其中ACS患者包括急性心肌梗死(acute myocardial infarction,AMI)组92例、不稳定型心绞痛(unstable angina pectoris,UAP)组66例,冠状动脉病变程度根据Gensini积分进行评估,对照组为同期行冠状动脉造影检查排除冠状动脉粥样硬化的患者。酶联免疫吸附测定(enzyme linked immunosorbent assay,ELISA)法测血浆sLRP-1、RANTES浓度。结果AMI组患者血浆lg sLRP-1和RANTES浓度[(0.69±0.20)mg/L与(125.17±34.87)ng/L]和UAP组[(0.62±0.19)mg/L与(118.51±21.46)ng/L]高于SAP组[(0.42±0.11)mg/L与(99.56±21.46)ng/L]和对照组[(0.27±0.08)mg/L与(98.39±19.37)ng/L](P均<0.05),而血浆lg sLRP-1和RNATES在AMI组与UAP组之间、SAP与对照组之间比较差异无统计学意义(P均>0.05)。ACS患者经PCI治疗后血浆lg sLRP-1和RANTES浓度较术前下降(P均<0.05);ACS患者血浆lg sLRP-1和RANTES浓度与Gensini积分无相关性(r值分别为0.12、0.22,P均>0.05)。结论ACS患者血浆sLRP-1和RANTES参与ACS的进展过程,并存在一定的相关性;心肌灌注治疗改善冠状动脉的炎症反应。
Objective To investigate the concentration of soluble low-density lipoprotein receptor-related protein-1(sLRP-1)and regulated upon activation normal T cell expressed and secreted(RANTES)in the plasma of patients with acute coronary syndrome(ACS)and the correlation with the severity of coronary artery disease,and to explore its clinical significance.Methods From January 2019 to July 2019,250 patients in the Department of Cardiology of the Affiliated Hospital of Chengde Medical College were selected for prospective study,including 158 patients with ACS,42 patients with stable angina pectoris(SAP)and 50 patients in the control group.ACS patients included 92 patients with acute myocardial infarction(AMI)and 66 patients with unstable angina pectoris(UAP).The degree of coronary artery lesions was evaluated according to the Gensini score.The patients in the control group were excluded from coronary atherosclerosis by coronary angiography at the same time.The concentrations of sLRP-1 and RANTES in plasma were measured by enzyme linked immunosorbent assay(ELISA).Results The plasma levels of lg sLRP-1 and RANTES in AMI group((0.69±0.20)mg/L and(125.17±34.87)ng/L)and UAP group((0.62±0.19)mg/L and(118.51±21.46)ng/L)were higher than SAP group((0.42±0.16)mg/L and(99.56±21.46)ng/L)and control group((0.27±0.08)mg/L and(98.39±19.37)ng/L)(all P<0.05),while lg sLRP-1 and RNATES levels were not significantly different between AMI group and UAP group,SAP group and control group(all P>0.05).The levels of lg sLRP-1 and RANTES in patients with ACS decreased after PCI treatment(all P<0.05).Plasma lg sLRP-1 and RANTES levels were not correlated with Gensini scores in ACS patients(all P>0.05).Conclusion SLRP-1 and RANTES are involved in the progression of ACS,and there is a certain correlation between them.Myocardial perfusion therapy improves the inflammatory response of coronary artery.
作者
田雅楠
胡娜
宋海玖
史菲
丁振江
Tian Yanan;Hu Na;Song Haijiu;Shi Fei;Ding Zhenjiang(Department of Cardiology,Affiliated Hospital of Chengde Medical College,Chengde 067000,China;Department of Cardiology,Southern District,Affiliated Hospital of Chengde Medical College,Chengde 067000,China;Department of Internal Medicine 1,Chengde Hospital of Traditional Chinese Medicine,Hebei Province,Chengde 067000,China)
出处
《中国综合临床》
2020年第3期202-206,共5页
Clinical Medicine of China
基金
河北省政府资助专科带头人项目(361008)
承德市科技发展项目(201801A055)。
