摘要
便秘是帕金森病最常见的前驱非运动症状之一,且便秘的严重程度与未来患帕金森病风险存在相关性。便秘不仅引起帕金森病患者临床相关症状,而且可通过对左旋多巴吸收的负面作用,影响帕金森病晚期患者运动波动的病理生理变化。便秘造成的高社会经济负担及帕金森病患者因便秘引发的其他肠道并发症迫切需要精准有效的治疗策略,需要深入了解影响帕金森病患者便秘的复杂病理生理学因素。因此,对帕金森病便秘发生机制的研究至关重要。本文将重点从帕金森病便秘的病理生理机制及治疗现状进行综述。
Constipation is one of the most common precursor non-motor symptoms of Parkinson disease,and the severity of constipation is associated with the risk of Parkinson disease in the future.Constipation not only causes clinical symptoms of Parkinson disease,but also affects the pathophysiological changes of movement fluctuations in patients with advanced Parkinson disease through its negative effects on the absorption of Levodopa.The high socio-economic burden of constipation and other constipation-related intestinal complications in patients with Parkinson disease call for an accurate and effective treatment strategy,which requires an in-depth understanding of the complex pathophysiological factors that affect constipation in patients with Parkinson disease.Therefore,it is very important to study the mechanism of constipation in Parkinson disease.This article will focus on the pathophysiological mechanism and treatment status of constipation in Parkinson disease.
作者
马雪
王强
王渊
袁伟
刘智斌
MA Xue;WANG Qiang;WANG Yuan;YUAN Wei;LIU Zhibin(College of Acupuncture and Moxibustion and Massage,Shaanxi University of Traditional Chinese Medicine,Shaanxi Province,Xianyang712046,China;the Third Clinical Medical College,Zhejiang Chinese Medical University,Zhejiang Province,Hangzhou310051,China;Shaanxi Key Laboratory of Acupuncture and Herbal Medicine,Shaanxi Province,Xianyang712046,China;Key Laboratory of Neurobiology(Acupuncture)of Xianyang,Shaanxi Province,Xianyang712046,China)
出处
《中国医药导报》
2021年第23期33-37,共5页
China Medical Herald
基金
国家自然科学基金资助项目(81873388)
陕西省科技计划项目(2020JM-594)
陕西中医药大学学科创新团队项目(2019-YL09)。
关键词
便秘
帕金森病
病理生理机制
治疗
Constipation
Parkinson disease
Pathogenesis
Treatment
