摘要
目的探讨三酰甘油与高密度脂蛋白胆固醇比值(TG/HDL⁃C)、血栓调节蛋白(TM)在老年股骨颈骨折术后深静脉血栓形成(DVT)患者的诊断价值。方法选取2015年1月至2020年1月本院收治的102例行股骨颈骨折手术老年患者,根据术后是否发生DVT分为DVT组(n=24)、无DVT组(n=78),比较两组基线资料、低密度脂蛋白胆固醇(LDL⁃C)、高密度脂蛋白胆固醇(HDL⁃C)、总胆固醇(TC)、三酰甘油(TG)、TG/HDL⁃C、TM水平,分析上述指标与Caprini血栓风险因素量表关系以及各指标与DVT易感性关系,评价各指标诊断DVT价值,并比较不同TG/HDL⁃C、TM水平患者DVT发生率。结果DVT组TG、TG/HDL⁃C、TM高于无DVT组,HDL⁃C低于无DVT组,差异有统计学意义(P<0.05)。TG、TG/HDL⁃C、TM与Caprini血栓风险因素量表评分呈正相关,HDL⁃C与Caprini血栓风险因素量表评分呈负相关(P<0.05)。将糖尿病、术中输血控制后,TG/HDL⁃C、TM仍与Caprini血栓风险因素量表评分相关(P<0.05)。TG/HDL⁃C联合TM诊断DVT的AUC最大,为0.883(P<0.05)。TG/HDL⁃C、TM高危患者DVT发生率高于低危患者(P<0.05)。结论TG/HDL⁃C、TM升高可能提高老年股骨颈骨折术后DVT易感性,联合检测上述指标有助于提高老年股骨颈骨折术后DVT诊断效能。
Objective To investigate the expression of triacylglycerol to high⁃density lipoprotein cholesterol ratio(TG/HDL⁃C)and thrombomodulin(TM)in elderly patients with deep vein thrombosis(DVT)after femoral neck fracture surgery,and to analyze the diagnostic value of the combination of the two for postoperative DVT,and provide scientific guidance for clinical prevention and treatment.Methods A to⁃tal of 102 elderly patients undergoing femoral neck fracture surgery admitted to our hospital from January 2015 to January 2020 were selected.According to whether DVT occurred after operation,they were divided into the DVT group(n=24)and the no DVT group(n=78).The baseline data,low⁃density lipoprotein cholesterol(LDL⁃C),high⁃density lipoprotein cholesterol(HDL⁃C),total cholesterol(TC),triacylglycerol(TG),TG/HDL⁃C,and TM levels were compared between the two groups.The relationship between the above indicators and the Caprini Thrombosis Risk Factor Scale and the relationship between each indicator and DVT susceptibil⁃ity were analyzed.The value of each indicator in diagnosing DVT was evaluated,and the incidence of DVT in patients with different TG/HDL⁃C and TM levels was compared.Results The TG,TG/HDL⁃C and TM in the DVT group were higher than those in the no DVT group,and HDL⁃C was lower than the no DVT group(P<0.05).TG,TG/HDL⁃C,TM were positively correlated with the Caprini Thrombosis Risk Factor Scale score,and HDL⁃C was negatively correlated with the Caprini Thrombosis Risk Factor Scale score(P<0.05).After di⁃abetes and intraoperative blood transfusion were controlled,TG/HDL⁃C and TM were still correlated with the Caprini Thrombosis Risk Factor Scale score(P<0.05).The AUC of TG/HDL⁃C combined with TM in the di⁃agnosis of DVT was the largest,which was 0.883(P<0.05).The incidence of DVT in high⁃risk patients with TG/HDL⁃C and TM was higher than that in low⁃risk patients(P<0.05).Conclusion Elevated TG/HDL⁃C and TM may increase the susceptibility of elderly patients with femoral neck fr
作者
焦义
杨治涛
罗伦
程环宇
JIAO Yi;YANG Zhitao;LUO Lun;CHENG Huanyu(Department of Orthopedics,Fuyang Women and Children's Hospital(Fuyang Sixth People's Hospital),Fuy-ang,Anhui,China,236000)
出处
《分子诊断与治疗杂志》
2021年第8期1321-1324,1328,共5页
Journal of Molecular Diagnostics and Therapy
基金
安徽省卫生健康委科研项目(AHWJ2021b063)。
关键词
三酰甘油
高密度脂蛋白胆固醇
血栓调节蛋白
老年
股骨颈骨折术
深静脉血栓形成
Triacylglycerol
High⁃density lipoprotein cholesterol
Thrombomodulin
Elderly
Femoral neck fracture surgery
Deep vein thrombosis
