摘要
目的探讨三酰甘油(triglycerides,TG)/高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)比值与青年缺血性卒中的相关性。方法回顾性纳入2019年1月至2020年6月期间连云港市第一人民医院收治的青年缺血性卒中患者(18~45岁)以及同期体检中心年龄和性别相匹配的健康对照者,收集人口统计学和相关临床资料。应用多变量logistic回归分析确定TG/HDL-C比值与青年缺血性卒中的独立相关性。结果共纳入112例青年缺血性卒中患者和60例健康对照者。病例组男性89例(79.5%),女性23例(20.5%);对照组男性49例(81.7%),女性11例(18.3%)。病例组基线TG(P=0.002)、HDL-C(P=0.001)以及TG/HDL-C比值(P=0.001)与对照组比较差异有统计学意义。多变量logistic回归分析显示,校正混杂因素后,TG/HDL-C比值较高是青年缺血性卒中的独立危险因素(以第1四分位数组为参照,第3四分位数组:优势比3.14,95%可信区间1.11~8.87,P<0.001;第4四分位数组:优势比3.87,95%可信区间1.24~12.09;P<0.001)。结论TG/HDL-C比值较高是青年缺血性卒中的独立危险因素。
Objective To investigate the correlation between triglycerides(TG)/high-density lipoprotein cholesterol(HDL-C)ratio and ischemic stroke in young adults.Methods From January 2019 to June 2020,young patients with ischemic stroke(18-45 years old)admitted to the First People's Hospital of Lianyungang and the age-and gender-matched healthy controls in the physical examination center during the same period were included retrospectively.The demographic and related clinical data were collected.Multivariate logistic regression analysis was used to identify the independent correlation between TG/HDL-C ratio and youth ischemic stroke.Results A total of 112 young patients with ischemic stroke and 60 healthy controls were included in the study.The age of the case group was 38.75±5.91 years.There were 89 males(79.5%)and 23 females(20.5%)in the case group,49 males(81.7%)and 11 females(18.3%)in the control group.There were significant differences in baseline TG(P=0.002),HDL-C(P=0.001)and TG/HDL-C ratio(P=0.001)between the two groups.Multivariate logistic regression analysis showed that after adjusting for confounding factors,higher TG/HDL-C ratio was an independent risk factor for ischemic stroke in young adults(compared with the first quartile,the third quartile:odds ratio 3.14,95%confidence interval 1.11-8.87,P<0.001;the fourth quartile:odds ratio 3.87,95%confidence interval 1.24-12.09,P<0.001).Conclusion Higher TG/HDL-C ratio is an independent risk factor for ischemic stroke in young adults.
作者
刘雨朦
金晶
张栋
葛建
陈思源
施海媛
何明利
Liu Yumeng;Jin Jing;Zhang Dong;Ge Jian;Chen Siyuan;Shi Haiyuan;He Mingli(Lianyungang School of Clinical Medicine,Nanjing Medical University,Lianyungang 222061,China;Department of Neurology,the Affiliated Lianyungang Hospital of Xuzhou Medical University,the First People's Hospital of Lianyungang,Lianyungang 222061,China)
出处
《国际脑血管病杂志》
2020年第12期899-903,共5页
International Journal of Cerebrovascular Diseases
基金
国家自然科学基金(81970348)。
