摘要
目的探究对氧磷脂酶1(PON1)、CD39/三磷酸腺苷(ATP)轴在急性百草枯中毒(APP)患者中的水平变化,并分析其预测预后价值。方法选取本院APP患者82例,根据90 d预后分为生存组(64例)与死亡组(18例),检测两组血浆PON1活性、CD39细胞比例、血清ATP水平,并分析其临床意义。结果死亡组血浆PON1活性、血清ATP水平低于生存组,CD39细胞比例高于生存组,差异有统计学意义(P<0.05);血浆PON1活性、血清ATP水平与中毒剂量(r=-0.698、-0.741)、中毒程度(r=-0.749、-0.725)呈负相关,CD39细胞比例与中毒剂量、中毒程度呈正相关(r=0.665、0.708,P<0.05);血浆PON1活性、CD39细胞比例、血清ATP水平是APP预后的重要影响因素(P<0.05);血浆PON1活性、CD39细胞比例、血清ATP水平预测APP预后的AUC均>0.7,各指标联合预测的AUC最大,为0.920,具有较高预测效能。结论血浆PON1活性、CD39细胞比例、血清ATP可作为预测APP患者预后的标志物。
Objective To explore the level changes of paraoxyphospholipase 1(PON1)and CD39/adenosine triphosphate(ATP)axis in patients with acute paraquat poisoning(APP),and analyze their prognostic value.Methods Eighty⁃two APP patients in our hospital were selected and divided into the surviv⁃al group(64 cases)and the death group(18 cases)according to the 90⁃day prognosis.The plasma PON1 activ⁃ity,CD39 cell ratio,and serum ATP level were detected in the two groups,and their clinical significance was analyzed.Results The plasma PON1 activity and serum ATP level of the death group were lower than those of the survival group,and the proportion of CD39 cells was higher than that of the survival group.The differ⁃ence was statistically significant(P<0.05).Plasma PON1 activity,serum ATP level and poisoning dose(r=-0.698,-0.741),the degree of poisoning(r=-0.749,-0.725)were negatively correlated,the proportion of CD39 cells was positively correlated with the dose of poisoning and the degree of poisoning(r=0.665,0.708,P<0.05).Plasma PON1 activity,the proportion of CD39 cells,and serum ATP level are important factors in the prognosis of APP(P<0.05).The AUC of plasma PON1 activity,CD39 cell ratio,and serum ATP level predicts APP prognosis>0.7,and the combination of each indicator is the largest,which is 0.920.Conclusion Plasma PON1 activity,CD39 cell ratio,and serum ATP can be used as markers to predict the prognosis of APP patients.
作者
张晓波
吕晓丹
周琴
林媛珍
李喆
刘达
吕立文
ZHANG Xiaobo;LV Xiaodan;ZHOU Qin;LIN Yuanzhen;LI Zhe;LIU Da;LV Liwen(Department of Emergency,the People's Hospital of Guangxi Zhuang Autonomous Region,Nanning,Chi-na,530021;Department of Clinical Laboratory,the First Affiliated Hospital of Guangxi Medical Universi-ty,Nanning,Guangxi,China,530000;Medical Record Room,Guangxi Zhuang Autonomous Region People's Hospital,Nanning,Guangxi,China,530021;Department of Respiratory Medicine,Guangxi People's Hospital,Nanning,Guangxi,China,530021;Department of Emergency,The Second Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi,China,530021)
出处
《分子诊断与治疗杂志》
2021年第8期1313-1316,共4页
Journal of Molecular Diagnostics and Therapy
基金
广西壮族自治区卫生和计划生育委员会自筹经费科研课题(Z20170354)。
