摘要
目的探讨急性重度有机磷农药中毒开始血液灌流治疗的时间与疗效的相关性。方法回顾性分析83例急性重度有机磷农药中毒患者,根据是否采用血液灌流治疗和血液灌流开始治疗的时间不同分为4组。灌流1组：在中毒12 h以内给予血液灌流治疗,1次/d,共2-3 d;灌流2组：在中毒12-24 h给予血液灌流治疗,1次/d,共2-3 d;灌流3组：在中毒24 h后给予血液灌流治疗,1次/d,共2-3 d;对照组：未采用血液灌流治疗。比较各组胆碱酯酶（ChE）活力恢复的时间。结果 4组患者治疗后1 d、2 d、3 d、4 d时ChE活力及50%ChE恢复时间（T50）比较,差异均有统计学意义（P〈0.05）。其中灌流3组上述各指标与对照组比较,差异均无统计学意义（P〉0.05）;而灌流1组与2组比较,差异均有统计学意义（P〈0.05）。结论在急性重度有机磷中毒常规治疗的基础上,血液灌流开始时间在中毒24 h内,尤其是在中毒12 h内具有很好的临床疗效。中毒24 h以后给予血液灌流治疗没有显著的临床疗效。
Objective To investigate the correlations between start time and effect in treatment of acute severe organophosphorus pesticide poisoning.by hemoperfusionMethods A total of 83 cases of severe acute organophosphorus pesticide poisoning were retrospectively reviewed and divided into 4 different groups,according to application status and start time of the treatment approach of hemoperfusion.Perfusion groups received hemoperfusion once per day for 2~3 days which started within 12 hours,between 12 hours to 24 hours,and after 24 hours for group A,B,and C,respectively;the control group on the other hand,received no hemoperfusion at all.Time of recoverment in terms of cholinesterase（ChE） activity of each group were measured and compared.Results ChE activity and half recovery time（T50） measured 1d,2d,3d,and 4d after treatment were significantly different among the four groups（P0.05）,between group A and the control group（P0.05）,between group B and the control group（P0.05）,whereas not statistically different between group C and the control group（P0.05）.Conclusion,Hemoperfusion,aside from conventional therapy,started within 24h,especially within 12h,might be of great clinical efficacy for treatment of acute severe organophosphorus pesticide poisoning,while hemoperfusion started 24h after the event may not be clinically effective.
出处
《中国全科医学》
CAS
CSCD
北大核心
2011年第14期1603-1604,1607,共3页
Chinese General Practice
关键词
有机磷农药
血液灌流
灌流起始时间
Organophosphorus pesticides
Hemoperfusion
Start time of hemoperfusion
