摘要
目的探讨SAMHD1在胃癌患者中的表达情况及其与患者预后的相关性。方法采用免疫组化染色法检测320例胃癌患者肿瘤组织中SAMHD1的表达情况,分析SAMHD1表达情况与临床病理特征及预后的相关性。结果胃癌组织中SAMHD1的阳性表达率高达75.9%。SAMHD1的表达情况与患者的性别和肿瘤原发部位无相关性,而与患者年龄和胃癌的临床分期相关(P<0.05)。Cox比例风险回归模型分析结果显示,SAMHD1表达情况、临床分期是胃癌患者预后的独立影响因素,SAMHD1表达阳性者的预后优于SAMHD1表达阴性者(均P<0.05)。结论胃癌组织中SAMHD1广泛表达,SAMHD1表达阳性是胃癌患者预后的独立保护因素,可以作为判断胃癌预后的指标。
Objective To explore the expression of SAMHD1 in patients with gastric cancer and its correlation with the prognosis of the patients.Methods Immunohistochemical staining method was used to detect the expression of SAMHD1 in tumor tissues of 320 patients with gastric cancer,and the correlation of SAMHD1 expression with clinicopathological features and prognosis was analyzed.Results The positive expression rate of SAMHD1 in gastric cancer tissues was as high as 75.9%.SAMHD1 expression did not correlate with patients′gender or tumor primary site,but was related to patients′age and clinical stage of gastric cancer(P<0.05).The results of Cox proportional hazard regression model analysis indicated that SAMHD1 expression and clinical stage were the independent influencing factor of prognosis in patients with gastric cancer,and patients with positive SAMHD1 expression had superior prognosis than those with negative SAMHD1 expression(all P<0.05).Conclusion SAMHD1 is extensively expressed in gastric cancer tissues,positive SAMHD1 expression is an independent protective factor for prognosis in patients with gastric cancer,and it can act as an indicator for prognosis judgment in gastric cancer.
作者
王健
李雪薇
徐钧
WANG Jian;LI Xue-wei;XU Jun(Department of General Surgery,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China)
出处
《广西医学》
CAS
2021年第12期1443-1446,共4页
Guangxi Medical Journal
关键词
胃癌
SAMHD1
表达
预后
相关性
影响因素
Gastric cancer
SAMHD1
Expression
Prognosis
Correlation
Influencing factor
