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SAMHD1抗肿瘤研究进展 被引量:4

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摘要 SAMHD1蛋白全称为不育-α-基序结构域(SAM域)和组氨酸/天冬氨酸残基双联体结构域(HD域)包涵蛋白1,是由真核生物SAMHD1基因编码的蛋白质。研究发现SAMHD1会在许多肿瘤中发生突变,并且它在肿瘤中的突变有功能性意义。SAMHD1具有dNTPase活性,能够调节细胞内dNTP的稳态,进而维持基因组的稳定性。
出处 《中国实验诊断学》 2018年第1期171-176,共6页 Chinese Journal of Laboratory Diagnosis
基金 吉林省教育厅"十二五"科学技术研究项目吉教科合字[2015]第349号
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