摘要
随着人们生活水平的不断提高,低毒、高效的天然抗氧化剂成为当下研究热点。多酚类、维生素类和多糖类化合物因具有较强的抗氧化活性而备受研究者关注。天然抗氧化剂与蛋白的结合可能会对其抗氧化活性产生影响。浓度是影响不同天然活性成分间抗氧化协同性的重要因素,抗氧化能力会随着活性成分浓度的增加而逐渐增强,但协同性不一定增强。此外,相同抗氧化剂的复配溶液在不同抗氧化模型中的协同性存在一定差异。响应曲面法可以为最大协同性配比的筛选提供实验方案。综述了天然抗氧化活性成分、蛋白对抗氧化性的影响、一些天然抗氧化剂之间的协同作用以及协同性的优化方法,以期为开发并优化具有协同作用的天然抗氧化剂提供思路。
With the continuous improvement of people's living standards,natural antioxidants with low toxicity and high efficacy have become a research hotspot.Polyphenols,vitamins and polysaccharide compounds have attracted much attention from researchers because of their strong antioxidant activity.The binding of natural antioxidants to proteins may affect their antioxidant activity.Concentration is an important factor affecting the antioxidant synergy between different natural active ingredients.The antioxidant ability of active ingredients will gradually increase with their increasing concentration,but their synergy may not necessarily increase.In addition,the synergy between the same antioxidants in the mixed solution is different in different antioxidant models.Response surface methodology(RSM)can provide experimental schemes for the screening of the ratios with the maximum synergy.In this paper,the natural antioxidant active ingredients,the influence of proteins on antioxidant activity,the synergistic effects of some natural antioxidants and the optimization methods for synergy were summarized.This will provide ideas for the development and optimization of synergistic natural antioxidants.
作者
刘贺
朱奕昊
刘亭亭
任永芳
王正平
刘敏
LIU He;ZHU Yihao;LIU Tingting;REN Yongfang;WANG Zhengping;LIU Min(School of Chemistry and Chemical Engineering,Liaocheng University,Liaocheng 252059,China;Institute of BioPharmaceutical Research,Liaocheng University,Liaocheng 252059,China;Liaocheng High-Tech Biotechnology Co.,Ltd.,Liaocheng 252059,China)
出处
《聊城大学学报（自然科学版）》
2021年第5期59-65,共7页
Journal of Liaocheng University:Natural Science Edition
基金
国家自然科学基金项目(22073039)资助。
关键词
天然抗氧化剂
协同作用
蛋白
响应曲面法
natural antioxidants
synergistic effect
proteins
response surface methodology
