摘要
系统性血管炎是一组异质性疾病,其病理特征为炎性血管损伤和血管闭塞。本病病因不清,可能与遗传、环境、表观修饰等有关。细胞外囊泡是由细胞分泌的具有信息传递功能的异质囊泡,目前研究发现,这些囊泡参与炎症、自身免疫反应、内皮功能障碍/损伤、促凝血、血管生成和内膜增生等与血管炎病理有关的过程。本文就细胞外囊泡在不同系统性血管炎亚型中的研究进展进行综述。
Systemic vasculitis is a group of heterogeneous diseases whose pathological features were inflammatory vascular injury and vascular occlusion.The specific etiology is unclear,and might be related to heredity,environment,and epigenetics.Extracellular vesicles are heterogeneous vesicles secreted by cells with information transmission function.Current studies had found that these vesicles were involved in the pathological process of vasculitis such as inflammation,autoimmune response,endothelial dysfunction or injury,blood coagulation,angiogenesis,and intimal hyperplasia.We reviewed the research progress of extracellular vesicles in different subtypes of systemic vasculitis.
出处
《中华临床免疫和变态反应杂志》
CAS
2021年第3期325-329,共5页
Chinese Journal of Allergy & Clinical Immunology
基金
国家自然科学基金(81401333)。
关键词
细胞外囊泡
系统性血管炎
自身免疫
炎症
extracellular vesicles
systemic vasculitis
autoimmunity
inflammation
