摘要
目的探讨内皮细胞微粒(EMPs)在过敏性紫癜患儿中的表达及意义。方法 100例初治过敏性紫癜患儿分为紫癜性肾炎组(HSPN组,40例)和非肾炎组(60例),并以30例健康体检儿童为对照组。采用流式细胞术或ELISA方法检测各组血清EMPs、Th17及IL-17的表达或含量。结果 Th17及IL-17在HSP的肾炎组和非肾炎组均高于对照组,以HSPN组最高,差异有统计学意义(P<0.05)。HSP肾炎组和非肾炎组的EMPs水平较对照组升高,以HSPN组最高,差异有统计学意义(P<0.05)。紫癜性肾炎组的Th17、IL-17水平与EMPs水平呈正相关(r=0.830、 0.644,P<0.05)。结论 EMPs在过敏性紫癜的发病机制中起一定作用,EMPs升高可能是过敏性紫癜患儿肾脏受累的原因之一。
Objective To study the expression and significance of endothelial microparticles（EMPs）in children with Henoch-Sch？nlein purpura（HSP）.Methods A total of 100 previously untreated children with HSP were classified to Henoch-Sch？nlein purpura nephritis（HSPN）group（n=40）and non-nephritis group（n=60）.Thirty healthy children who underwent physical examination were enrolled as control group.Serum levels of EMPs,T helper 17 cells（Th17）,and interleukin-17（IL-17）were compared between groups.Results The HSPN and non-nephritis groups had significantly higher levels of Th17 and IL-17 than the control group,and the HSPN group had the highest levels（P〈0.05）.The HSPN and non-nephritis groups had a significantly higher level of EMPs than the control group,and the HSPN group had the highest level（P〈0.05）.In the HSPN group,the levels of Th17 and IL-17 were positively correlated with the level of EMPs（r=0.830 and 0.644 respectively;P〈0.05）.Conclusions EMPs play an important role in the pathogenesis of HSP.The increase in EMPs might be one of the reasons for renal involvement in children with HSP.
作者
付书琴
郭燕军
宋春兰
FU Shu-Qin;G UO Yan-Jun;SONG Chun-Lan(Children＇s Hospital of Zhengzhou University/Children＇s Hospital of Henan Province/Zhengzhou Children＇s Hospital/Zhengzhou Children＇s Critical Medical Key Laboratory,Zhengzhou 450000,China)
出处
《中国当代儿科杂志》
CAS
CSCD
北大核心
2018年第10期831-834,共4页
Chinese Journal of Contemporary Pediatrics
关键词
内皮细胞微粒
过敏性紫癜
紫癜性肾炎
儿童
Endothelial microparticle
Henoch-Schonlein purpura
Henoch-Schonlein purpura nephritis
Child
