摘要
阿尔兹海默病(AD)是一种常见的神经系统退行性病变,也是造成老年痴呆最常见的病因之一,其在全球范围内的发病率逐年增高,然而几乎所有针对经典发病机制的药物都未取得令人满意的临床效果。这使得科学家逐渐从简单的淀粉样蛋白假说转向新的发病机制理论,包括伽玛振荡、朊病毒样传播、脑血管收缩、生长激素促分泌素受体1α通路的作用、微生物感染、炎症消散障碍。本文论述了相关进展,以期对AD的发病机制和未来治疗策略提供参考。
Alzheimer's disease(AD)is a common neurodegenerative disease and one of the most common causes of senile dementia.The incidence rate of AD is increasing year by year globally,however,almost all the drugs targeting the classic pathogenesis have not achieved satisfactory clinical results.This has led scientists to gradually shift from the simple amyloid hypothesis to new pathogenesis theories,including gamma oscillation,prion-like transmission,cerebral vasoconstriction,the role of the growth hormone secretagogue receptor 1α(GHSR1α)pathway,microbial infection,and dissipation of inflammation disorder.This article reviews the progress in the understanding of the pathogenesis of AD and provides a perspective on future treatment strategies.
作者
苏霄
赵世刚
赵婷婷
岳晓蓉
Su Xiao;Zhao Shigang;Zhao Tingting;Yue Xiaorong(Department of Neurology,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)
出处
《中华临床医师杂志（电子版）》
CAS
北大核心
2021年第3期224-228,共5页
Chinese Journal of Clinicians(Electronic Edition)
关键词
阿尔兹海默病
发病机制
治疗靶点
Alzheimer's disease
Pathogenesis
Therapeutic target
