摘要
射频电磁场(radio-frequency electromagnetic field,RF-EMF)广泛存在于生产生活中,以非热效应作用于机体,通过长期RF-EMF暴露可能产生不同的生物学效应。大脑是对RF-EMF暴露敏感的靶器官之一,常表现在学习和记忆功能的改变,目前RF-EMF对学习和记忆功能的影响仍存在争论。近年来,研究发现RF-EMF长时间暴露与阿尔兹海默病(Alzheimer’s disease,AD)的发病和病程进展有关,可能通过影响AD患者脑内β-淀粉样蛋白(β-amyloid,Aβ)水平和Aβ通路下游的其他反应、激活自噬和抑制凋亡,起到保护神经元作用,从而改善AD的学习和记忆功能。目前对AD的研究仍处于初级阶段,仍未发现AD的病因和有效治疗方法。研究RF-EMF暴露对AD的影响可能为AD相关研究提供新线索。本文对射频电磁场对AD病理性改变和认知功能的影响进行综述,为AD相关研究提供依据。
Radio-frequency electromagnetic fields(RF-EMF)are widely existing in production and life,which act on the body with non-thermal effects.Different biological effects may occur through long-term RF-EMF exposure.The brain is one of the target organs that sensitive to RF-EMF exposure.RF-EMF exposure may alter learning and memory function.The effects of RF-EMF on learning and memory function are still debated.In recent years,studies have found that prolonged exposure to RF-EMF is associated with the onset and progression of Alzheimer’s disease(AD).It may improve learning and memory function in AD by affectingβ-amyloid(Aβ)levels and other responses downstream of the Aβpathway,activating autophagy and inhibiting apoptosis in the brain of AD,which may have a protective effect on neurons.At present,the research into AD is still in its infancy and the causes and effective treatments for AD have still not been identified.Studying the effects of RF-EMF exposure on AD may provide new leads for AD-related research.The article review the effects of RF-EMF on pathological changes and cognitive function in AD and provide a basis for AD-related research.
作者
蒋玉融
吴锡南
张盛庆宇
李志强
舒逍
武慧欣
JIANG Yu-rong;WU Xi-nan;ZHANG Sheng-qingyu;LI Zhi-qiang;SHU Xiao;WU Hui-xin(School of Basic Medicine,Kunming Medical University,Kunming Yunnan,650500,China;Graduate Faculty,Kunming Medical University,Kunming Yunnan,650500,China;School of Public Health,Kunming Medical University,Kunming Yunnan,650500,China)
出处
《职业与健康》
CAS
2023年第1期122-125,130,共5页
Occupation and Health
基金
国家自然科学基金项目(82060587)
云南省科技厅科技计划项目(202101AY070001-056)
云南省科技厅科技计划项目(202101AY070001-057)。
关键词
射频电磁场
阿尔茨海默病
生物学效应
病理性改变
认知功能
Radio-frequency electromagnetic fields
Alzheimer’s disease
Biological effect
Pathological changes
Cognitive function
