摘要
目的探究临床常用的3种抗精神病药物对尿常规检测结果的影响,并提出相应的预防对策。方法选择2019年4—12月在福州市精神病人疗养院就诊的132例精神病患者为研究对象,根据其治疗药物种类不同分为氯氮平组(n=44)、氯丙嗪组(n=44)和利培酮组(n=44),另选2019年4—12月在福州市精神病人疗养院就诊的44例未服用过抗精神病药物的首诊精神分裂症患者设为对照组。在氯氮平组、氯丙嗪组、利培酮组用药前、用药4周后以及对照组首诊时采用尿液分析仪、显微镜进行尿常规检测,比较四组尿液分析仪、尿镜检的检测结果。结果对照组患者与氯氮平组、利培酮组、氯丙嗪组患者用药前的尿白细胞、尿酮体、尿胆红素、尿糖、尿蛋白检测阳性率比较,差异无统计学意义(P>0.05)。但氯氮平组、利培酮组患者用药后的尿酮体、尿糖阳性率显著高于用药前和对照组,氯丙嗪组用药后的尿胆红素、尿蛋白阳性率显著高于用药前和对照组(P<0.05)。四组患者用药前后的尿镜检红细胞、白细胞、管型、上皮细胞、结晶阳性率比较,差异无统计学意义(P>0.05)。结论抗精神病药物可导致尿液分析仪测定的尿常规结果异常,故对于行尿常规的精神病患者需在检测前询问清楚患者用药史,并对尿液分析仪检测阳性者进一步行镜检复检,以提高疾病诊断的准确性。
Objective To explore the influence of three commonly used clinical antipsychotics on the results of urine routine tests,and to propose corresponding preventive measures.Methods One hundred and thirty-two psychiatric patients treated in Fuzhou Mental Patient Sanatorium from April to December 2019 were selected as the research objects and divided into the clozapine group(n=44),the chlorpromazine group(n=44)and the risperidone group(n=44)according to the different types of drugs administered.Another 44 patients with first diagnosed schizophrenia who did not take antipsychotics in our hospital from April to December 2019 were selected as the control group.Routine urine tests were performed using urine analyzer and microscopy before and 4 weeks after treatment in the clozapine group,chlorpromazine group,and risperidone group,and at the first visit of the control group,and the results of urine analyzers and urine microscopy tests in the four groups were compared.Results There were no statistically significant differences in the positive rates of urine white blood cells,urine ketones,urine bilirubin,urine glucose,and urine protein tests between the control group and the clozapine group,risperidone group,and chlorpromazine group before treatment(P>0.05).However,the positive rates of urine ketones and urine glucose tests in the clozapine group and risperidone group after treatment were significantly higher than those before the treatment and those in the control group.The positive rates of urine bilirubin and urine protein tests in the chlorpromazine group were significantly higher than those before treatment and those in the control group(P<0.05).There were no statistically significant differences in the positive rates of red blood cells,white blood cells,casts,epithelial cells,and crystals detected by urine microscopy tests before and after the treatment for the four groups of patients(P>0.05).Conclusion Antipsychotics can cause abnormal urine routine test results measured by urine analyzer.Therefore,the patient’s med
作者
陈素双
李曲文
CHEN Sushuang;LI Quwen(Department of Laboratory Medicine,Fuzhou Mental Patient Sanatorium,Fujian,Fuzhou 350008,China;Fujian Provincial Center for Disease Control and Prevention,Fujian,Fuzhou 350001,China)
出处
《中国医药科学》
2021年第13期126-129,共4页
China Medicine And Pharmacy
关键词
尿常规
氯氮平
利培酮
氯丙嗪
假阳性
Urine routine tests
Clozapine
Risperidone
Chlorpromazine
False positive
