摘要
近年来,妊娠期亚临床甲状腺功能减退症(SCH)的发病率逐年上升,妊娠期并发症和不良妊娠结局的发生风险增加,导致子代神经发育受损。左甲状腺素钠片中所含有的合成左甲状腺素与人体内的内源性甲状腺素结构相同,是治疗SCH的首选药物。目前,甲状腺过氧化物酶抗体(TPOAb)阳性SCH孕妇给予口服左甲状腺素治疗,但对TPOAb阴性SCH孕妇的治疗建议并未统一,且左甲状腺素钠的治疗剂量、TSH的干预范围、不同孕期的获益、临床疗效、子代智力和患者接受度仍存在争议。
In recent years,the incidence of subclinical hypothyroidism(SCH)during pregnancy has been increasing year by year,and the risk of pregnancy complications and adverse pregnancy outcomes has increased,leading to impaired neurodevelopment in the offsprings.Synthetic levothyroxine,which is contained in levothyroxine sodium tablets,has the same structure as endogenous thyroxine in the human body and is the preferred drug of choice for the treatment of SCH.Currently,pregnant women with thyroid peroxidase antibody(TPOAb)positive SCH are given oral levothyroxine therapy,but treatment recommendations for pregnant women with TPOAb negative SCH are not unified,and the therapeutic dose of levothyroxine sodium,the scope of SCH intervention,the benefits for different gestational periods,the clinical efficacy,the offspring intelligence,and the patient acceptance are still controversial.
作者
张泰魏
万菁菁
邹严
卞靖瞳
杜鑫
周意园
ZHANG Taiwei;WAN Jingjing;ZOU Yan;BIAN Jingtong;DU Xin;ZHOU Yiyuan(Department of Obstetrics,the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550001,China;Department of Cardiovascular Medicine,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;Department of Obstetrics and Gynecology,Peking Union Medical College Hospital,Beijing 100005,China;Department of Reproductive Medicine,Women and Children′s Hospital,Qingdao University,Qingdao 266000,China)
出处
《医学综述》
CAS
2021年第14期2814-2818,共5页
Medical Recapitulate
基金
国家自然科学基金(82060881)
贵阳市科技计划项目(筑科合同〔2019〕041号)
贵州中医药大学学术新苗培养及创新探索专项项目(黔科合平台人才〔2018〕5576号-02)。
