摘要
新型冠状病毒肺炎(COVID-19)疫情已在全球范围内蔓延并造成大流行。引起此次疫情的病原体为新型冠状病毒(SARS-CoV-2),其与严重急性呼吸综合征(SARS)及中东呼吸综合征(MERS)的病原体均属于冠状病毒,传染性强,易引起重症肺炎,目前无特异性治疗药物。随着COVID-19疫情的蔓延及扩散,疫苗接种已成为当前的迫切需求。该文主要介绍冠状病毒感染相关的机体免疫保护机制,阐述新型冠状病毒疫苗研发的关键抗原S蛋白,并就冠状病毒目前疫苗研发的安全性、有效性及潜在问题进行总结。
The outbreak of coronavirus disease 2019(COVID-19)has become a global pandemic.The pathogen responsible for this disease is a novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).It belongs to coronavirus family,a pathogen similar to SARS and Middle East respiratory syndrome(MERS),and manifests strong infectivity and pathogenicity to progress into severe pneumonia.Till now,there is no specific therapeutic drug targeting against this virus.With the rapid spread and deterioration of the epidemic situation,vaccination has become an urgent need.This review introduces the immune defense mechanism of human body against coronavirus briefly,set forth the key viral spike protein for coronavirus vaccine development,and then summarize the recent advances/progresses and potential challenges in safety and efficacy of vaccine development for SARS-CoV-2.
作者
钱汐晶
万彩虹
赵平
戚中田
Qian Xi-Jing;Wan Cai-Hong;Zhao Ping;Qi Zhong-Tian(Department of Biomedical Defense,Faculty of Naval Medicine,Naval Medical University,Shanghai 200433,China)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2021年第7期710-717,共8页
Medical Journal of Chinese People's Liberation Army
基金
国家传染病重大专项课题(2017ZX10304403-003)。
