摘要
比较目前在全球范围内有代表性的新型冠状病毒候选疫苗,为新型冠状病毒疫苗研发提供更新的更全面的参考。本综述总结了新型冠状病毒疫苗的病毒学与免疫学基础,对部分基于不同技术的、有代表性的以及已经进入2a/3期临床试验的候选疫苗进行了详细的比较和分析。全球进入3期临床试验的多种新型冠状病毒疫苗免疫效果令人鼓舞,但疫苗免疫原性与安全性的关系、临床试验数据的可靠性等方面仍然需要密切关注。设计新的疫苗靶标、诱导更广泛的免疫保护、改善免疫原性、严格各期临床试验、建立大规模队列研究是对新型冠状病毒疫苗研发提出的更高要求。
To compare the representative novel coronavirus vaccine in the world at present and to provide a new and more comprehensive reference for the research and development of novel coronavirus vaccine.This review summarized the virological and immunological basis of novel coronavirus vaccine and made a detailed comparison and analysis of some representative vaccines based on different technologies and clinical trials in phase 2a/3.The immune effect of many kinds of novel coronavirus vaccines in phase 3 clinical trials around the world is encouraging,but the relationship between vaccine immunogenicity and safety and the reliability of clinical trial data still need to be paid close attention to.Designing new vaccine targets,inducing more extensive immune protection,improving immunogenicity,strict clinical trials and establishing large-scale cohort studies are higher requirements for novel coronavirus vaccine research and development.
作者
梁耀民
林正方
杨小云
王忠芳
Liang Yaomin;Lin Zhengfang;Yang Xiaoyun;Wang Zhongfang(KingMed School of Laboratory Medicine,Guangzhou Medical University,Guangzhou 510180,China;State Key Laboratory of Respiratory Disease,Guangzhou Medical University,Guangzhou 510180,China)
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
2021年第3期349-356,共8页
Chinese Journal of Experimental and Clinical Virology
关键词
新型冠状病毒
疫苗
免疫
抗体
T细胞
2019 novel coronavirus
Vaccine
Immunity
Antibody
T cells
