摘要
目的:观察四妙勇安汤加减联合PRP技术治疗糖尿病足湿性坏疽的临床效果和安全性。方法:选择2018年6月-2019年12月黑龙江中医药大学附属第一医院收治的80例糖尿病足湿性坏疽患者,将患者随机分为观察组和对照组,每组40例。对照组给予常规基础治疗及四妙勇安汤加减治疗,观察组在对照组基础上联用PRP技术。比较两组治疗前后创面面积,视觉模拟评分法(VAS)评估治疗前后疼痛程度,免疫吸附试验检测创面组织肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)以及细胞间黏附分子-1(ICAM-1)水平,比较两组创面愈合时间和住院时间及临床疗效。结果:治疗前及治疗1周后,两组患者的创面面积比较,差异均无统计学意义(P>0.05);治疗2、3、4周后,观察组患者的创面面积均明显小于对照组,差异均有统计学意义(P<0.05);治疗结束后,观察组的创面缩小率优于对照组,差异有统计学意义(P<0.05)。治疗2、3、4周后,观察组VAS评分均明显低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组TNF-α、IL-6、ICAM-1水平均明显下降,且观察组均明显低于对照组,差异均有统计学意义(P<0.05)。观察组创面愈合时间、住院时间均短于对照组,差异均有统计学意义(P<0.05)。观察组患者的临床总有效率为92.50%,高于对照组的75.00%,差异有统计学意义(P<0.05)。两组均未发生明显不良反应。结论:四妙勇安汤加减联合PRP技术治疗糖尿病足湿性坏疽具有显著效果,能更好控制炎症,减轻疼痛和加速愈合,值得临床推广。
Objective:To observe the clinical effect and safety of Simiao Yongan Decoction combined with PRP technology in the treatment of diabetic foot wet gangrene.Method:A total of 80 patients with wet gangrene of diabetic foot disease admitted to the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from June 2018 to December 2019 were selected.The patients were randomly divided into observation group and control group,40 cases in each group.The control group was treated with conventional basic treatment and Simiao Yongan Decoction,and the observation group was combined with PRP technology on the basis of the control group.The wound area was compared between the two groups before and after treatment.The degree of pain was assessed by visual analogue scale(VAS).The levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and intercellular adhesion molecule-1(ICAM-1)in the wound tissues were detected by immunoadsorption assay.Wound healing time,hospital stay and clinical efficacy were compared between the two groups.Result:Before treatment and 1 week after treatment,there were no significant differences in the wound area between two groups(P>0.05).After 2,3 and 4 weeks of treatment,the wound area of the observation group were significantly smaller than those of the control group,the differences were statistically significant(P<0.05).After treatment,the wound reduction rate in the observation group was better than that in the control group,the difference was statistically significant(P<0.05).After 2,3 and 4 weeks of treatment,the VAS score of the observation group were significantly lower than those of the control group,the differences were statistically significant(P<0.05).After treatment,the levels of TNF-α,IL-6 and ICAM-1 in both groups were significantly decreased,and the observation group were significantly lower than those of the control group,the differences were statistically significant(P<0.05).The wound healing time and hospitalization time of the observation group were shorter than t
作者
付大鹏
刘岐
陈文阁
FU Dapeng;LIU Qi;CHEN Wen’ge(Heilongjiang University of Chinese Medicine,Harbin 150040,China;不详)
出处
《中国医学创新》
CAS
2021年第20期85-89,共5页
Medical Innovation of China
基金
黑龙江省自然科学基金面上项目(H201475)。
