摘要
目的探讨氧化应激因子水平与精神分裂症患者认知功能的相关性。方法选择2019年3月至2020年11月杭州市余杭区第一人民医院(以下简称“我院”)就诊的50例首次发病且未服药精神分裂症患者为病例组。选择同期来我院的50名健康志愿者为对照组。检测两组丙二醛(MDA)、谷胱甘肽(GSH)、同型半胱氨酸(Hcy)和超氧化物歧化酶(SOD)的水平。使用精神分裂症认知功能成套测验(MCCB)评估两组认知功能,分析上述氧化应激因子水平与认知功能的关系。结果病例组在信息处理速度、注意/警觉性、工作记忆、词语学习、视觉学习、推理和问题解决能力和社会认知方面均显著低于对照组(P<0.05)。病例组SOD和GSH水平明显低于对照组;Hcy和MAD水平显著高于对照组(P<0.05)。精神分裂症患者Hcy及MDA水平与注意/警觉性均呈负相关(P<0.05);其他氧化应激因子水平与认知功能未见明显相关性(P>0.05)。结论精神分裂症患者处于氧化应激状态,抗氧化能力显著降低,Hcy与MDA的水平可能影响精神分裂症患者认知功能。
Objective To investigate the relationship between oxidative stress factor levels and cognitive impairment in patients with schizophrenia.Methods A total of 50 patients with first onset and unmedicated schizophrenia who were admitted to the First People’s Hospital of Yuhang District of Hangzhou(“our hospital”for short)from March 2019 to November 2020 were selected as case groups.A total of 50 healthy people who were admitted to our hospital during the same period were selected as control group.The levels of malondialdehyde(MDA),glutathione(GSH),homocysteine(Hcy),and superoxide dismutase(SOD)were measured.The MACTICS consensus cognitive battery(MCCB)was used to assess cognitive impairment in both groups,and the relationship between the above oxidative stress factor levels and cognitive impairment in schizophrenia was analyzed.Results The case group was significantly lower than the control group in terms of information processing speed,attention/alertness,working memory,word learning,visual learning,reasoning and problem solving obility,and social cognition(P<0.05).The levels of SOD and GSH in the case group were significantly lower than those in the control group(P<0.05).The levels of Hcy and MAD in the case group were significantly higher than those in the control group(P<0.05).The levels of Hcy and MDA in patients with schizophrenia were negatively correlated with attention/alertness(P<0.05).There was no obvious correlation between the levels of other oxidative stress factors and cognitive impairment(P>0.05).Conclusion Patients with schizophrenia are in oxidative stress state,and their antioxidant capacity is significantly reduced.The levels of Hcy and MDA affect cognitive impairment in patients with schizophrenia.
作者
沈禹泽
严辞
郜彬
孙敏
SHEN Yuze;YAN Ci;GAO Bin;SUN Min(Department of Mental Health,the First People’s Hospital of Yuhang District of Hangzhou,Zhejiang Province,Hangzhou 311100,China;Department of Psychiatry,Hangzhou Seventh People’s Hospital,Zhejiang Province,Hangzhou 310007,China;Department of Mental Health,the Second Affiliated Hospital of Zhejiang University College of Medicine,Zhejiang Province,Hangzhou 310009,China)
出处
《中国医药导报》
CAS
2021年第20期100-103,共4页
China Medical Herald
基金
浙江省自然科学基金青年基金项目(LQ19H090020)。
