摘要
苯并[a]芘广泛存在于食品、空气、水源等中,具有强烈的致癌性、致畸性和致突变性,其在人体内可以被代谢成多种对人体有害的物质。其中部分代谢产物(如苯并[a]芘-7,8-二氢二醇-9,10-环氧化物、苯并[a]芘-7,8-二酮、自由基阳离子)会与DNA形成加合物,进而诱导基因突变,引发疾病,如结肠癌、肺癌、胃癌等。苯并[a]芘及其代谢产物与DNA加合物的检测对保障食品安全和预防疾病发展具有重要意义。该文详细综述了苯并[a]芘及其代谢产物与DNA加合物的检测方法,为分析检测苯并[a]芘和预防其毒性提供参考,进而保障人体健康。
Benzo[a]pyrene is widely found in food,air,and water,which has strong carcinogenicity,teratogenicity and mutagenicity ability.It can be metabolized into a variety of substances harmful to the human body.Some of the metabolites(such as benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide,benzo[a]pyrene-7,8-dione,free radical cations)could form adducts with DNA,and then induce gene mutation and cause disease.The detection of benzo[a]pyrene and its metabolites and DNA adducts are of great significance for ensuring food safety and preventing disease development.This paper summarized in detail the detection methods of benzo[a]pyrene and its metabolites and DNA adducts in order to provide a reference for analysis and detection of benzo[a]pyrene and prevention of its toxicity,and then protect human health.
作者
王珠琳
袁莉
张萌
WANG Zhulin;YUAN Li;ZHANG Meng(College of Food Engineering and Nutritional Sciences,Shaanxi Normal University,Xi′an 710119,China)
出处
《食品与发酵工业》
CAS
CSCD
北大核心
2021年第14期287-293,共7页
Food and Fermentation Industries
基金
国家自然科学基金面上项目(31972183)
西安市青年人才托举计划(095920201311)
中央高校基本科研业务费专项资金资助(GK202002006)。
