摘要
尾型同源盒转录因子2(CDX2)是一种肠特异性核转录因子,主要表达于小肠和结直肠,在正常胃黏膜不表达。CDX2参与了胃肠道肿瘤的发生、发展、侵袭和转移,其表达状态与胃肠道肿瘤患者的临床病理特征及预后相关。深入研究CDX2参与肿瘤发生发展的相关机制及其与临床病理特征及预后的关系,有望为胃肠道肿瘤的诊断及治疗提供新的思路。
Caudal type homeobox transcription factor 2(CDX2)is an enteric-specific nuclear transcription factor,which is mainly expressed in the small intestine and colorectum and not expressed in normal gastric mucosa.CDX2 is involved in the occurrence,development,invasion and metastasis of gastrointestinal tumors,and its expression state is related to the clinicopathological characteristics and prognosis of patients with gastrointestinal tumors.It is expected to provide a new idea for the diagnosis and treatment of gastrointestinal tumors by further studying the mechanism of CDX2 involvement in tumor genesis and development and its relationship with clinicopathological features and prognosis.
作者
居欣月
胡春梅
赵月
唐艳
Ju Xinyue;Hu Chunmei;Zhao Yue;Tang Yan(Department of Tumor Hematology,Second Hospital of Jilin University,Changchun 130041,China)
出处
《国际肿瘤学杂志》
CAS
2021年第6期374-376,共3页
Journal of International Oncology
基金
吉林省自然科学基金(20200201368JC)。
关键词
CDX2转录因子
消化系统肿瘤
肠化生
CDX2 transcription factor
Digestive system neoplasms
Intestinal metaplasia
