摘要
目的探讨高危型人乳头瘤病毒(HR-HPV)感染的转归特点及阴道微环境因子对其转归的影响。方法从本课题组前期建立的社区队列中,选取HR-HPV感染、经病理学诊断为正常宫颈的421名女性为研究对象,进行24个月的随访。在收集基线资料的基础上,应用需氧菌性阴道炎/细菌性阴道病联合检测试剂盒测定阴道微环境因子,采用导流杂交技术检测HPV感染状况。根据基线和随访24个月后HR-HPV的感染状况,描述HR-HPV感染的转归特征,并探讨阴道微环境因子对HR-HPV感染转归的影响。结果在390名完成24个月随访的HR-HPV感染女性中,HR-HPV持续感染率居前5位的型别依次为HPV16(24.1%)、HPV58(22.2%)、HPV53(21.7%)、HPV52(20.0%)和HPV39(11.8%)。阴道pH值(aOR=1.74,95%CI:1.08~2.80)、唾液酸苷酶(aOR=2.70,95%CI:1.52~4.83)和白细胞酯酶(aOR=3.41,95%CI:2.13~5.44)异常可增加HR-HPV持续感染的风险,其中唾液酸苷酶和白细胞酯酶异常均可增加同型和异型HR-HPV持续感染的风险。结论HPV16容易发生持续感染,阴道pH值、唾液酸苷酶和白细胞酯酶异常可增加HR-HPV持续感染的风险,特别是唾液酸苷酶、白细胞酯酶异常作用更为明显。
Objective To describe the characteristics of high-risk human papillomavirus(HR-HPV)infection and its influences by vaginal micro-environmental factors.Methods A total of 421 women with HR-HPV infection and normal cervix diagnosed by pathology were selected from a community cohort established earlier by our research group for a 24-month follow-up.The baseline data were collected at enrollment.The vaginal micro-environmental factors were detected by using the combined detection kit of aerobic vaginitis and bacterial vaginosis.And the HPV was detected by using the flow-through hybridization technology.According to the HR-HPV infection status in baseline and 24 months of follow-up,with the prognosis characteristics of HR-HPV infection described,the impact of vaginal micro-environmental factors on the prognosis of HR-HPV infection was explored as well.Results Among 390 HR-HPV infected women who completed 24 months of follow-up,the top five types of persistent HR-HPV infection rate appeared as HPV16(24.1%),HPV58(22.2%),HPV53(21.7%),HPV52(20.0%),and HPV39(11.8%),respectively.The results showed that women with abnormal vaginal pH(aOR=1.74,95%CI:1.08-2.80),abnormal neuraminidase(aOR=2.70,95%CI:1.52-4.83),or abnormal leucocyte esterase(aOR=3.41,95%CI:2.13-5.44),the risk of HR-HPV persistent infection increased.The abnormalities of neuraminidase and leukocyte esterase could increase the risk of persistent infection of homotype and heterotypic HR-HPV.Conclusions HPV16 was prone to persistent infection.Abnormalities of vaginal pH,neuraminidase,and leukocyte esterase might increase the risk of HR-HPV persistent infection.Both the abnormalities of neuraminidase and leukocyte esterase play an essential role in the HR-HPV persistent infection.
作者
孟丹
宋丽
祁卓
王捷
刘虹
吕元婧
贾海霞
丁玲
郝敏
田志强
王金桃
Meng Dan;Song Li;Qi Zhuo;Wang Jie;Liu Hong;Lyu Yuanjing;Jia Haixia;Ding Ling;Hao Min;Tian Zhiqiang;Wang Jintao(Department of Epidemiology,School of Public Health,Shanxi Medical University,Taiyuan 030001,China;Department of Obstetrics and Gynecology,Second Hospital of Shanxi Medical University,Taiyuan 030001,China;Stomatological Hospital of Shanxi Medical University,Taiyuan 030001,China)
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2021年第6期1103-1107,共5页
Chinese Journal of Epidemiology
基金
国家自然科学基金(81872705,81473060,81703313)
国家卫生和计划生育委员会公益性行业科研专项(201402010)。
关键词
阴道微环境因子
高危型人乳头瘤病毒
转归
Vaginal micro-environmental factors
High-risk human papillomavirus
Prognosis
