摘要
目的分析热淋清颗粒配合常规抗生素治疗淋病的临床价值。方法选取2018年2月—2020年6月期间河北省衡水市第二人民医院皮肤科收治的88例淋病患者,按照随机数字表法将其分为对照组与治疗组,每组44例。对照组给予常规抗生素(头孢地嗪钠)治疗,治疗组在对照组基础上联合热淋清颗粒治疗,两组患者均治疗2周,治疗期间禁止性生活,注意局部卫生等。治疗后比较两组患者临床疗效、治疗前后血清炎症介质[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)]水平、生活质量(SF-12评分)改善情况及治疗安全性。治疗结束后随访4周,统计比较两组患者复发率。结果治疗后对照组治疗总有效率为81.40%(35/43),治疗组为95.45%(42/44),两组比较,差异有统计学意义(P<0.05)。治疗后两组患者血清TNF-α、IL-6、IL-10水平均较治疗前降低,差异有统计学意义(P<0.05);且治疗组治疗后血清TNF-α、IL-6、IL-10水平均低于对照组,两组比较,差异有统计学意义(P<0.05)。治疗后两组患者SF-12评分均较治疗前升高,差异有统计学意义(P<0.05);且治疗组治疗后SF-12评分高于对照组,两组比较,差异有统计学意义(P<0.05)。治疗后两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。治疗结束后随访4周,治疗组复发率为2.27%(1/44),与对照组11.63%(5/43)比较,差异无统计学意义(P>0.05)。结论热淋清颗粒辅助头孢类抗生素治疗淋病安全、有效,可显著下调血清TNF-α、IL-6、IL-10等炎症介质表达,有利于改善患者生活质量。
Objective To analyze the clinical value of Relinqing Granules combined with conventional antibiotics in the treatment of gonorrhea.Methods From February 2018 to June 2020,88 gonorrhea patients admitted to the Department of Dermatology,Second People′s Hospital of Hengshui City,Hebei Province were selected and divided into a control group and a treatment group according to a random number table,with 44 cases in each group.The control group was treated with conventional antibiotics(ceftizine sodium),and the treatment group was treated with Relinqing Granules on the basis of the control group.Patients in both groups were treated for 2 weeks.During the treatment,sexual life was prohibited and local hygiene was paid attention to.After treatment,the clinical efficacy,serum levels of inflammatory mediators[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-10(IL-10)]were compared between the two groups of patients before and after treatment.Quality of life(SF-12 score)improvement and treatment safety.After treatment,the patients were followed up for 4 weeks,and the recurrence rates of the two groups were statistically compared.Results After treatment,the total effective rate of treatment in the control group was 81.40%(35/43),and the treatment group was 95.45%(42/44).The difference between the two groups was statistically significant(P<0.05).After treatment,the levels of serum TNF-α,IL-6,and IL-10 in the two groups were lower than those before treatment,and the difference was statistically significant(P<0.05);and the levels of serum TNF-α,IL-6,and IL-10 levels in the treatment group was lower than the control group after treatment.And the difference between the two groups was statistically significant(P<0.05).After treatment,the SF-12 scores of the two groups of patients were higher than before treatment,thedifference was statistically significant(P<0.05);and the SF-12 scores of the treatment group after treatment were higher than those of the control group,and the difference between the two groups w
作者
南海峰
刘杰
吴丹
李静
姬艳尊
NAN Hai-feng;LIU Jie;WU Dan;LI Jing;JI Yan-zun(Department of Dermatology,Second People′s Hospital of Hengshui City,Hebei Province,Hengshui Hebei 053000)
出处
《世界中西医结合杂志》
2021年第6期1103-1107,共5页
World Journal of Integrated Traditional and Western Medicine
基金
河北省中医药管理局科研计划项目(2019346)。
关键词
淋病
头孢类抗生素
热淋清颗粒
血清炎症介质
生活质量
Gonorrhea
Cephalosporins
Relinqing Granules
Serum Inflammatory Mediators
Quality of Life
