摘要
目的观察二黄膏外敷联合西医常规疗法治疗急性痛风性关节炎临床疗效。方法采用随机数字表法将80例患者分为对照组和治疗组各40例。对照组予西医常规治疗,治疗组在对照组基础上予二黄膏外敷患膝,4 h/次,2次/d。2组均治疗1周,随访3个月。比较2组临床症状、实验室检查、超声声像图及不良反应,评价2组临床疗效及安全性指标。结果与本组治疗前比较,2组治疗后临床症状评分、视觉模拟评分法评分及白细胞计数、血尿酸、C反应蛋白、红细胞沉降率、白细胞介素(IL)-1β、IL-6、肿瘤坏死因子-α水平明显下降(P<0.05);2组治疗后比较,治疗组上述指标均明显低于对照组(P<0.05)。与本组治疗前比较,治疗组治疗后膝关节积液、滑膜增生明显改善(P<0.05);2组治疗后比较,治疗组膝关节积液及滑膜增生改善均优于对照组,且能明显减轻软骨厚度变薄(P<0.05)。治疗组总有效率为95.0%(38/40),对照组为87.5%(35/40),治疗组临床疗效优于对照组(P<0.05)。对照组出现不良反应2例,治疗组未见不良反应。随访时对照组复发1例。结论在西医常规治疗基础上联合二黄膏外敷治疗急性痛风性关节炎疗效较好,可明显改善患者临床症状和炎症性指标,减轻膝关节积液、滑膜增生。
Objective To observe the clinical efficacy of external application of Erhuang Ointment combined with Western medicine routine therapy on acute gouty arthritis.Methods Totally 80 patients with acute gouty arthritis were divided into control group and treatment group according to random number table method,with 40 cases in each group.The control group was given routine Western medicine treatment,and the treatment group was given Erhuang Ointment for external application on the basis of the treatment of the control group,4 h/time,twice a day.The treatment for both groups lasted for 1 week and followed up for 3 months.Clinical symptoms,laboratory examinations,ultrasound images and adverse reactions of the two groups were compared.Clinical efficacy and safety indicators of both groups were evaluated.Results Compared with before treatment,clinical symptoms,white blood cell count,blood uric acid,C-reactive protein,erythrocyte sedimentation rate,IL-1β,IL-6 and TNF-αwere significantly improved(P<0.05);after treatment,the above indicators in the treatment group were significantly lower than those in the control group(P<0.05).Compared with before treatment,the knee joint effusion and synovial hyperplasia in the treatment group were significantly improved after treatment(P<0.05);after treatment,the improvement of knee joint effusion and synovial hyperplasia in the treatment group was better than that in the control group,and it could significantly reduce cartilage thickness thinning(P<0.05).The total effective rate was 95.0%(38/40)in the treatment group,and 87.5%(35/40)in the control group.The clinical efficacy of the treatment group was better than that of the control group(P<0.05).There were 2 cases of adverse reactions in the control group and no adverse reactions in the treatment group.1 case in the control group relapsed during follow-up.Conclusion On the routine Western medicine treatment,external application of Erhuang Ointment can significantly improve the clinical symptoms and inflammatory indicators of patients w
作者
段连香
陈杰
刘子洋
廖琳
郭玥
路建饶
DUAN Lianxiang;CHEN Jie;LIU Ziyang;LIAO Lin;GUO Yue;LU Jianrao(The Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200137,China;Ye Jinghua National Famous Old Traditional Chinese Medicine Inheritance Studio,Shanghai 200137,China)
出处
《中国中医药信息杂志》
CAS
CSCD
2021年第7期107-111,共5页
Chinese Journal of Information on Traditional Chinese Medicine
基金
上海市第七人民医院“七院新星(中医类)”人才培养计划项目(XX2020-25)
上海市进一步加快中医药事业发展三年行动计划中医优势病种培育建设项目[ZY(2018-2020)-ZYBZ-19]
上海市浦东新区卫生和计划生育委员会临床中医高峰学科建设计划(PDZY-2018-0601)。
关键词
二黄膏
痛风性关节炎
炎症因子
超声检查
临床研究
Erhuang Ointment
gouty arthritis
inflammatory factors
ultrasonography
clinical study
