摘要
目的分析1990~2019年中国女性宫颈癌发病、死亡和疾病负担的变化趋势。方法采用全球疾病负担(GBD)数据库与《中国卫生健康统计年鉴》数据,利用Excel、SPSS 21.0与Joinpoint Regression Program 4.8.0.1软件分析中国女性宫颈癌发病率、年龄标化发病率、死亡率、年龄标化死亡率、城市与农村死亡率及疾病负担、年度变化百分比(APC)等指标,分析中国女性宫颈癌的疾病负担变化。结果1990~2019年,中国女性宫颈癌年龄标化发病率由9.21/10万增加到12.06/10万,年龄标化死亡率由8.40/10万下降到7.36/10万。2018年城市与农村宫颈癌标化死亡率均较2015年有所下降。年龄别发病率变化提示宫颈癌发病呈现年轻化趋势。伤残调整寿命年(DALY)、过早死亡损失寿命年(YLL)、伤残损失寿命年(YLD)等疾病负担指标分别由1990年的86.49、84.01、1.52万人年增加至2019年的162.22、157.40、4.83万人年,APC分别为2.39%、2.56%、4.25%,变化趋势差异有统计学意义(P<0.05)。其中以YLD增长幅度最大,增幅达到217.76%。2019年宫颈癌占女性恶性肿瘤所致DALY、YLL、YLD均较1990年有所增加。40岁以上年龄组DALY、YLL、YLD均增加,其中50~54岁年龄组DALY值增加了167.15%。结论我国是宫颈癌患病大国。尽管近年来死亡率有下降趋势,但宫颈癌防治现状仍不容乐观。中国女性宫颈癌发病呈现年轻化趋势,疾病负担呈上升趋势,应采取积极预防措施以减轻宫颈癌的疾病负担。
Objective To analyze the trends of incidence,mortality,and burden of disease of cervical cancer in Chinese females from 1990 to 2019.Methods The global burden of disease database(GBD)and China health statistics yearbook data was used to analyze the incidence,standardized incidence,mortality,standardized mortality,urban and rural mortality,and burden of cervical cancer among Chinese females using Excel,SPSS 21.0 and Joinpoint Regression Program 4.8.0.1.Results The standardized incidence of cervical cancer among Chinese females increased from 9.21/100000 in 1990 to 12.06/100000 in 2019,and the standardized mortality decreased from 8.40/100000 to 7.36/100000.The standardized mortality of cervical cancer in 2018 decreased when compared with 2015 in both urban and rural areas.Changes in age-group incidence and mortality indicated that there was a younger trend in cervical cancer.The disease burden indicators(DALY,YLL,and YLD)were increased from 86.49,84.01,and 1.52 ten thousand person/years to162.22,157.40,and 4.83 ten thousand person/years,in which the YLD increased the most(217.76%).The APC of DALY,YLL and YLD were 2.39%,2.56%and 4.25%,respectively.The proportion of cervical cancer disease burden in female cancer increased in 2019 compared with 1990.And DALY,YLL and YLD increased in the age group of 40 or over,in which DALY of the age group 50-54 increased 167.15%.Conclusions The situation of cervical cancer is not optimistic in China.Although the mortality of cervical cancer has decreased in recent years,the number of cases and mortalities is still increasing.Not only the burden of disease is continuously increasing,there is also a younger trend in cervical cancer.Active preventive measures should be taken to reduce the burden of cervical cancer.
作者
孟令昊
胥秋艳
李科
许文丽
黄磊
MENG Linghao;XU Qiuyan;LI Ke;XU Wenli;HUANG Lei(West China School of Medicine and West China Hospital,Sichuan University,Chengdu 610041,P.R.China;West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu 610041,P.R.China;Department of Chronic Disease Prevention and Control,Guangzhou Center for Disease Control and Prevention,Guangzhou 510440,P.R.China;China Birth Defects Monitoring Center,West China Second Hospital,Sichuan University,Chengdu 610041,P.R.China)
出处
《中国循证医学杂志》
CSCD
北大核心
2021年第6期648-653,共6页
Chinese Journal of Evidence-based Medicine
关键词
宫颈癌
发病率
死亡率
疾病负担
Cervical cancer
Incidence
Mortality
Burden of disease
