摘要
目的 了解山东省东营市适龄女性HPV感染情况,为合理制定精准防控策略提供科学依据。方法 选择2017—2018年山东省东营市参与“两癌筛查”的35~64岁女性常住人口为调查对象,采用荧光定量聚合酶链式反应法对14种高危型HPV亚型进行检测,收集该人群基本信息和HPV感染情况等数据,进行流行病学特征分析。结果 共调查适龄女性213 020人,平均年龄(49.02±7.64)岁;2017—2018年东营市共检出HPV阳性者18 463例,阳性检出率为8.67%,其中HPV16阳性者3 429例,阳性检出率1.61%,HPV18阳性者1 177例,阳性检出率0.55%,其他高危型别HPV阳性者15 352例,阳性检出率7.21%;在全部14种高危型别HPV阳性检出情况中,35~<40岁年龄段女性检出率最高,随后呈现下降趋势,≥55岁有小幅度上升趋势;东营区、广饶区、垦利区、广饶县、利津县14种高危型别HPV检出率分别为7.91%、8.02%、9.55%、8.95%和8.39%,地区差异具有统计学意义(χ^(2)=80.621,P<0.05),而东营区HPV16、HPV18的阳性检出率分别为1.39%和0.38%,比其他县区低;城镇和农村居民中全部14种高危型别HPV阳性检出率分别为9.76%和8.46%,差异具有统计学意义(χ^(2)=60.976,P<0.05),进一步根据县(区)进行分类,结果显示,东营区、河口区和垦利区城镇各型HPV阳性检出率均高于农村,但广饶县和利津县HPV16和HPV18的阳性检出率在城乡间的差异无统计学意义(χ^(2)=0.422,0.289,0.023,1.452,P>0.05)。结论 山东省东营市适龄女性HPV感染率处于较低水平;HPV感染的年轻化趋势明显,有关部门应该做好重点人群的监测与筛查,并提高城镇居民“两癌筛查”的覆盖率。
Objective Through the spatial description of the HPV infection of the females in Dongying City,Shandong Province,we provide a scientific evidence for making precision prevention and control strategies.MethodsIn this study,we selected the female residents aged 35 to 64 who participated in the cervical cancer and breast cancer screening in Dongying City,Shandong Province from 2017 to 2018 as the objects.The fluorescence quantitative polymerase chain reaction method was used to detect 14 high-risk HPV subtypes,and then we collected their basic and HPV infection information to analyze epidemiological characteristics.ResultsA total of 213 020 people were investigated in this study,with an average age of(49.02±7.64) years.From 2017 to 2018,18 463 cases of HPV positive were detected in Dongying City,with a positive rate of8.67%.Among them,HPV16-positive,HPV18-positive and other high-risk types of HPV-positive were 3 429 cases (1.61%),1 177 cases (0.55%),and 15 352 cases (7.21%) respectively.The positive detection rate of all 14 high-risk types of HPV was highest among women in the 35-<40 age,and then showed a downward trend,with a slight upward trend after the age of 55.The positive detection rate of all 14 high-risk types of HPV in Dongying District,Guangrao District,Kenli District,Guangrao County,and Lijin County were 7.91%,8.02%,9.55%,8.95%,and 8.39%,respectively,and the regional differences were statistically significant (χ^(2)=80.621,P<0.05).The positive detection rate of HPV16 and HPV18 in Dongying District was the lowest compared with other counties (HPV16:1.39%,HPV18:0.38%).The positive detection rate of all 14 high-risk types of HPV among urban and rural residents were 9.76%and 8.46%,and the difference was statistically significant (χ^(2)=60.976,P<0.05).Further classification according to counties (districts),the results showed that the positive detection rate of all types of HPV among urban residents were higher than those in rural areas in all counties (districts) except for Lijin County.However,the positi
作者
周慧慧
王娜
郑燕京
刘占红
王文军
ZHOU Hui-hui;WANG Na;ZHENG Yan-jing;LIU Zhan-hong;WANG Wen-jun(Jining Medical Colloge,Jining,Shandong 272067,China;Dongying Municipal Health Commission,Dongying,Shandong 257091,China)
出处
《中国热带医学》
CAS
2022年第3期258-261,共4页
China Tropical Medicine
基金
济宁医学院青年教师科研扶持基金-扶贫专项(No.JYFC2019FP003)。
关键词
人乳头瘤病毒
宫颈癌
常住人口
普查
human papillomavirus(HPV)
cervical cancer
permanent residents
census
