摘要
目的探讨瑞舒伐他汀钙治疗功能性室性期前收缩患者的疗效及对炎症因子的影响。方法选择2018年9月~2020年7月收治的功能性室性期前收缩患者122例,根据随机数字表法,将其分为观察组与对照组,每组61例。对照组给予常规药物治疗,观察组在对照组基础上给予瑞舒伐他汀钙治疗,两组均治疗观察1个月,记录临床疗效。结果治疗后观察组的总有效率为98.4%,显著高于对照组的88.5%(P<0.05)。两组治疗后的TC、TG、LDL-C值都显著低于治疗前,HDL-C值高于治疗前(P<0.05),观察组与对照组对比差异也有统计学意义(P<0.05)。两组治疗后的LVEDV与LVESV值都显著低于治疗前(P<0.05),观察组也显著低于对照组(P<0.05)。两组治疗后的血清CRP值都显著低于治疗前(P<0.05),观察组也显著低于对照组(P<0.05)。结论瑞舒伐他汀钙治疗功能性室性期前收缩患者能抑制炎症因子的释放,改善血脂水平,从而提高患者的心功能与治疗效果。
Objective To investigate the clinical effects of rosuvastatin calcium in the treatment of functional ventricular premature systolic patients.Methods From September 2018 to July 2020,122 patients with functional ventricular premature contractions in our hospital were equally divided into the observation group and the control group according to the randomly number table method.The control group were given conventional drug treatment,and the observation group were given rosuvastatin calcium on the basis of the control group.Both groups were treated for 1 month,and the clinical efficacy were recorded.Results The total effective rates of the observation group after treatment was 98.4%,which was significantly higher than that of the control group(88.5%)(P<0.05).The TC,TG and LDL-C values of the two groups after treatment were significantly lower than those before treatment,and the HDL-C value were higher than that before treatment(P<0.05),and the difference compared between the observation group and the control group were also statistically significant(P<0.05).The LVEDV and LVESV values of the two groups after treatment were significantly lower than those before treatment(P<0.05),and the observation group were also significantly lower than the control group(P<0.05).The serum CRP values after treatment of the two groups were significantly lower than those before treatment(P<0.05),and the observation group were also significantly lower than the control group(P<0.05).Conclusion Rosuvastatin calcium can inhibit the release of inflammatory factors and improve blood lipid levels in patients with functional ventricular premature contraction,thus improve the heart function and therapeutic effect of patients.
作者
卢妍
张振国
赵晓倩
LU Yan;ZHANG Zhen-guo;ZHAO Xiao-qian(Internist Department,Tianjin Permanent Hospital,Tianjin 300450,China)
出处
《中国处方药》
2021年第6期107-109,共3页
Journal of China Prescription Drug
关键词
瑞舒伐他汀钙
功能性室性期前收缩
炎症因子
血脂
心功能
Rosuvastatin calcium
Functional ventricular premature contraction
Inflammatory factors
Blood lipids
Cardiac function
