摘要
目的:评价益心舒胶囊(人参、丹参、麦冬、黄芪等)在心律失常早搏中的有效性及安全性。方法:分别对60例房性早搏及60例室性早博的病人进行随机分组对照研究。房早或室早试验组各30例给予益心舒加异搏定或美西律;对照组30例单独给予异博定或美西律,疗程均为4周,行24h动态心电图检查。结果:在试验组与对照组,用药4周后房性或室性早博数较用药前明显减少(P<0.01,P<0.05),且治疗后试验组早博数明显低于对照组。益心舒加异博定总有效率为90,明显高于异博定对照组(66)(P<0.01);益心舒加美西律总有效率为97,明显高于美西律对照组(73)(P<0.01)。两试验组益心舒治疗后心肌缺血明显改善。结论:益心舒联合异博定或美西律治疗早搏疗效显著,优于单独应用异博定或美西律治疗。
AIM： To find a new way of treating premature beats（PB） to evaluate the efficacy and safety of Yixinshu Capsule （Radix et Rhizoma Ginseng, Radix et Rhizoma Salviae miltiorrhizae, Radix Ophiopogonis, Radix Astragali, etc. ） METHODS ： Randomized, controlled clinical study were conducted in 60 patients with atrial premature beats （ APB）, and 60 patients with premature ventricular beats （PVB）. APB patients were randomly divided into two groups ： Yixinshu Capsule plus Isoptin （ study group, n = 30） and Isoptin group （ control group, n = 30）. PVB patients： Yixinshu Capsule plus Mexiletine （study group, n = 30） and Mexiletine group （control group, n = 30）. Those patients were treated for four weeks. We used 24 h Holter to monitor the times of PB and myocardial ischemia in before and after treatment. RESULTS ： In the study group and control group, the times of APB and PVB were decreased obviously after 4 weeks treatment （P 〈0.01, P 〈0.05）. There were statistical difference in the times of PB between study and control group after treatments. The total efficacy rate in the group of Yixinshu Capsule combined with Isoptin（90% ） was higher than that of the group of Isoptin （66%） （P 〈0.01 ）. The total efficacy rate in the group of Yixinshu Capsule combined with Mexiletine （97%） was higher than that of the group of Mexiletine （73%） （ P 〈 0.01 ）. CONCLUSION ： The efficacy of Yixinshu Capsule combined with Isoptin or Mexiletine in treatment of APB or PVB is very obvious, and is better than that of Isoptin or Mexiletine alone.
出处
《中成药》
CAS
CSCD
北大核心
2007年第6期791-794,共4页
Chinese Traditional Patent Medicine
关键词
益心舒
异博定
美西律
房性早搏
室性早博
Yixinshu Capsule
Isoptin
Mexiletine
atrial premature beats
premature ventricular beats
