摘要
目的:优化化瘀骨合片的提取工艺条件。方法:以牡荆苷含量、芍药苷含量和固形物质量为评价指标,在单因素试验的基础上设计正交试验,考察料液比、提取时间、提取次数对提取工艺的影响,优化提取工艺条件。结果:最佳工艺条件为全方药材加水提取3次,每次加12倍量水提取2h,该条件下牡荆苷的提取率为89.81%,芍药苷的提取率为86.08%。结论:优选的提取工艺稳定,指标成分的提取率高,工艺合理可行。
Objective: To optimize the extraction process forHuayu Guhe tablets.Methods: With the content of vitexin, the content of paeoniflorin, and solid content mass as assessment indices, an orthogonal test was designed on the basis of single-factor experiment to investigate the influence of solid-liquid ratio, extraction time, and times of extraction on extraction process and optimize the conditions of the extraction process.Results: The optimal conditions of extraction were as follows: the medicinal materials of the whole prescriptionwere mixed with water(12 times),and extraction was performed 3 times, for 2 hours each.The extraction rates of vitexin and paeoniflorin were 89.81%and 86.08%,respectively, under such conditions.Conclusion: The optimized extraction process is stable and can achieve a high extraction rate of index components, and therefore, this process is reasonable and feasible.
作者
李洁环
张建军
陈雪婷
冯健英
李智勇
徐文杰
LI Jiehuan;ZHANG Jianjun;CHEN Xueting;FENG Jianying;LI Zhiyong;XU Wenjie(Guangdong Second Provincial Traditional Chinese Medicine Hospital(Guangdong Research Institute of Traditional Chinese Medicine Manufacturing Technology)/Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Research and Development,Guangzhou 510095,Guangdong,China)
出处
《湖南中医杂志》
2021年第5期174-178,共5页
Hunan Journal of Traditional Chinese Medicine
基金
广东省科技计划项目(2017A070701017)
广东省中医药科技创新平台建设项目(粤中医函[2017]340号)。
关键词
化瘀骨合片
提取工艺
正交试验
主成分分析
Huayu Guhe tablets
extraction process
orthogonal test
principal component analysis
